Enabling accurate and early detection of recently emerged SARS-CoV-2 variants of concern in wastewater

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As clinical testing declines, wastewater monitoring can provide crucial surveillance on the emergence of SARS-CoV-2 variant of concerns (VoCs) in communities. In this paper we present QuaID, a novel bioinformatics tool for VoC detection based on quasi-unique mutations. The benefits of QuaID are three-fold: (i) provides up to 3-week earlier VoC detection, (ii) accurate VoC detection (>95% precision on simulated benchmarks), and (iii) leverages all mutational signatures (including insertions & deletions).

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Sapoval, Nicolae, Liu, Yunxi, Lou, Esther G., et al.. "Enabling accurate and early detection of recently emerged SARS-CoV-2 variants of concern in wastewater." Nature Communications, 14, (2023) Springer Nature: https://doi.org/10.1038/s41467-023-38184-3.

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