Intercellular Stress Reconstitution from Traction Force Data

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dc.citation.firstpage548en_US
dc.citation.issueNumber3en_US
dc.citation.journalTitleBiophysical Journalen_US
dc.citation.lastpage554en_US
dc.citation.volumeNumber107en_US
dc.contributor.authorZimmermann, Julianeen_US
dc.contributor.authorHayes, Ryan L.en_US
dc.contributor.authorBasan, Markusen_US
dc.contributor.authorOnuchic, José N.en_US
dc.contributor.authorRappel, Wouter-Janen_US
dc.contributor.authorLevine, Herberten_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2014-09-09T16:04:21Zen_US
dc.date.available2014-09-09T16:04:21Zen_US
dc.date.issued2014en_US
dc.description.abstractCells migrate collectively during development, wound healing, and cancer metastasis. Recently, a method has been developed to recover intercellular stress in monolayers from measured traction forces upon the substrate. To calculate stress maps in two dimensions, the cell sheet was assumed to behave like an elastic material, and it remains unclear to what extent this assumption is valid. In this study, we simulate our recently developed model for collective cell migration, and compute intercellular stress maps using the method employed in the experiments. We also compute these maps using a method that does not depend on the traction forces or material properties. The two independently obtained stress patterns agree well for the parameters we have probed and provide a verification of the validity of the experimental method.en_US
dc.identifier.citationZimmermann, Juliane, Hayes, Ryan L., Basan, Markus, et al.. "Intercellular Stress Reconstitution from Traction Force Data." <i>Biophysical Journal,</i> 107, no. 3 (2014) Elsevier: 548-554. http://dx.doi.org/10.1016/j.bpj.2014.06.036.en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.bpj.2014.06.036en_US
dc.identifier.urihttps://hdl.handle.net/1911/77153en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.titleIntercellular Stress Reconstitution from Traction Force Dataen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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