Intercellular Stress Reconstitution from Traction Force Data

Simple item page
dc.citation.firstpage548
dc.citation.issueNumber3
dc.citation.journalTitleBiophysical Journal
dc.citation.lastpage554
dc.citation.volumeNumber107
dc.contributor.authorZimmermann, Juliane
dc.contributor.authorHayes, Ryan L.
dc.contributor.authorBasan, Markus
dc.contributor.authorOnuchic, José N.
dc.contributor.authorRappel, Wouter-Jan
dc.contributor.authorLevine, Herbert
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2014-09-09T16:04:21Z
dc.date.available2014-09-09T16:04:21Z
dc.date.issued2014
dc.description.abstractCells migrate collectively during development, wound healing, and cancer metastasis. Recently, a method has been developed to recover intercellular stress in monolayers from measured traction forces upon the substrate. To calculate stress maps in two dimensions, the cell sheet was assumed to behave like an elastic material, and it remains unclear to what extent this assumption is valid. In this study, we simulate our recently developed model for collective cell migration, and compute intercellular stress maps using the method employed in the experiments. We also compute these maps using a method that does not depend on the traction forces or material properties. The two independently obtained stress patterns agree well for the parameters we have probed and provide a verification of the validity of the experimental method.
dc.identifier.citationZimmermann, Juliane, Hayes, Ryan L., Basan, Markus, et al.. "Intercellular Stress Reconstitution from Traction Force Data." <i>Biophysical Journal,</i> 107, no. 3 (2014) Elsevier: 548-554. http://dx.doi.org/10.1016/j.bpj.2014.06.036.
dc.identifier.doihttp://dx.doi.org/10.1016/j.bpj.2014.06.036
dc.identifier.urihttps://hdl.handle.net/1911/77153
dc.language.isoeng
dc.publisherElsevier
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.titleIntercellular Stress Reconstitution from Traction Force Data
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
bpj_stress_manuscript.pdf
Size:
7.22 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications