Intercellular Stress Reconstitution from Traction Force Data
Date
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Cells migrate collectively during development, wound healing, and cancer metastasis. Recently, a method has been developed to recover intercellular stress in monolayers from measured traction forces upon the substrate. To calculate stress maps in two dimensions, the cell sheet was assumed to behave like an elastic material, and it remains unclear to what extent this assumption is valid. In this study, we simulate our recently developed model for collective cell migration, and compute intercellular stress maps using the method employed in the experiments. We also compute these maps using a method that does not depend on the traction forces or material properties. The two independently obtained stress patterns agree well for the parameters we have probed and provide a verification of the validity of the experimental method.
Description
Advisor
Degree
Type
Keywords
Citation
Zimmermann, Juliane, Hayes, Ryan L., Basan, Markus, et al.. "Intercellular Stress Reconstitution from Traction Force Data." Biophysical Journal, 107, no. 3 (2014) Elsevier: 548-554. http://dx.doi.org/10.1016/j.bpj.2014.06.036.