Intensity modulated proton arc therapy via geometry-based energy selection for ependymoma

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dc.citation.articleNumbere13954en_US
dc.citation.issueNumber7en_US
dc.citation.journalTitleJournal of Applied Clinical Medical Physicsen_US
dc.citation.volumeNumber24en_US
dc.contributor.authorCao, Wenhuaen_US
dc.contributor.authorLi, Yupengen_US
dc.contributor.authorZhang, Xiaodongen_US
dc.contributor.authorPoenisch, Falken_US
dc.contributor.authorYepes, Pabloen_US
dc.contributor.authorSahoo, Narayanen_US
dc.contributor.authorGrosshans, Daviden_US
dc.contributor.authorMcGovern, Susanen_US
dc.contributor.authorGunn, G. Brandonen_US
dc.contributor.authorFrank, Steven J.en_US
dc.contributor.authorZhu, Xiaorong R.en_US
dc.date.accessioned2023-08-01T17:29:39Zen_US
dc.date.available2023-08-01T17:29:39Zen_US
dc.date.issued2023en_US
dc.description.abstractPurpose We developed and tested a novel method of creating intensity modulated proton arc therapy (IMPAT) plans that uses computing resources similar to those for regular intensity-modulated proton therapy (IMPT) plans and may offer a dosimetric benefit for patients with ependymoma or similar tumor geometries. Methods Our IMPAT planning method consists of a geometry-based energy selection step with major scanning spot contributions as inputs computed using ray-tracing and single-Gaussian approximation of lateral spot profiles. Based on the geometric relation of scanning spots and dose voxels, our energy selection module selects a minimum set of energy layers at each gantry angle such that each target voxel is covered by sufficient scanning spots as specified by the planner, with dose contributions above the specified threshold. Finally, IMPAT plans are generated by robustly optimizing scanning spots of the selected energy layers using a commercial proton treatment planning system (TPS). The IMPAT plan quality was assessed for four ependymoma patients. Reference three-field IMPT plans were created with similar planning objective functions and compared with the IMPAT plans. Results In all plans, the prescribed dose covered 95% of the clinical target volume (CTV) while maintaining similar maximum doses for the brainstem. While IMPAT and IMPT achieved comparable plan robustness, the IMPAT plans achieved better homogeneity and conformity than the IMPT plans. The IMPAT plans also exhibited higher relative biological effectiveness (RBE) enhancement than did the corresponding reference IMPT plans for the CTV in all four patients and brainstem in three of them. Conclusions The proposed method demonstrated potential as an efficient technique for IMPAT planning and may offer a dosimetric benefit for patients with ependymoma or tumors in close proximity to critical organs. IMPAT plans created using this method had elevated RBE enhancement associated with increased linear energy transfer (LET) in both targets and abutting critical organs.en_US
dc.identifier.citationCao, Wenhua, Li, Yupeng, Zhang, Xiaodong, et al.. "Intensity modulated proton arc therapy via geometry-based energy selection for ependymoma." <i>Journal of Applied Clinical Medical Physics,</i> 24, no. 7 (2023) Wiley: https://doi.org/10.1002/acm2.13954.en_US
dc.identifier.digital2023-Caoen_US
dc.identifier.doihttps://doi.org/10.1002/acm2.13954en_US
dc.identifier.urihttps://hdl.handle.net/1911/115035en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleIntensity modulated proton arc therapy via geometry-based energy selection for ependymomaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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