Pulsed-multiline excitation for color-blind fluorescence detection

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dc.contributor.assigneeBaylor College of Medicineen_US
dc.contributor.assigneeRice Universityen_US
dc.contributor.publisherUnited States Patent and Trademark Officeen_US
dc.creatorScott, Graham B. I.en_US
dc.creatorKittrell, Carter W.en_US
dc.creatorCurl, Robert F.en_US
dc.creatorMetzker, Michael L.en_US
dc.date.accessioned2015-05-04T19:05:50Zen_US
dc.date.available2015-05-04T19:05:50Zen_US
dc.date.filed2005-10-12en_US
dc.date.issued2009-03-31en_US
dc.description.abstractThe present invention provides a technology called Pulse-Multiline Excitation or PME. This technology provides a novel approach to fluorescence detection with application for high-throughput identification of informative SNPs, which could lead to more accurate diagnosis of inherited disease, better prognosis of risk susceptibilities, or identification of sporadic mutations. The PME technology has two main advantages that significantly increase fluorescence sensitivity: (1) optimal excitation of all fluorophores in the genomic assay and (2) “color-blind” detection, which collects considerably more light than standard wavelength resolved detection. This technology differs significantly from the current state-of-the-art DNA sequencing instrumentation, which features single source excitation and color dispersion for DNA sequence identification. Successful implementation of the PME technology will have broad application for routine usage in clinical diagnostics, forensics, and general sequencing methodologies and will have the capability, flexibility, and portability of targeted sequence variation assays for a large majority of the population.en_US
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes.en_US
dc.format.extent28 ppen_US
dc.identifier.citationScott, Graham B. I., Kittrell, Carter W., Curl, Robert F. and Metzker, Michael L., "Pulsed-multiline excitation for color-blind fluorescence detection." Patent US7511811B2. issued 2009-03-31. Retrieved from https://hdl.handle.net/1911/79988.en_US
dc.identifier.patentIDUS7511811B2en_US
dc.identifier.urihttps://hdl.handle.net/1911/79988en_US
dc.language.isoengen_US
dc.titlePulsed-multiline excitation for color-blind fluorescence detectionen_US
dc.typeUtility patenten_US
dc.type.dcmiTexten_US
dc.type.genrepatentsen_US
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