Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?

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dc.citation.firstpage739
dc.citation.issueNumber7
dc.citation.journalTitleMolecular Oncology
dc.citation.lastpage754
dc.citation.volumeNumber11
dc.contributor.authorJolly, Mohit Kumar
dc.contributor.authorTripathi, Satyendra C.
dc.contributor.authorSomarelli, Jason A.
dc.contributor.authorHanash, Samir M.
dc.contributor.authorLevine, Herbert
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2017-08-21T14:34:15Z
dc.date.available2017-08-21T14:34:15Z
dc.date.issued2017
dc.description.abstractPhenotypic plasticity, the ability of cells to reversibly alter their phenotypes in response to signals, presents a significant clinical challenge to treating solid tumors. Tumor cells utilize phenotypic plasticity to evade therapies, metastasize, and colonize distant organs. As a result, phenotypic plasticity can accelerate tumor progression. A well-studied example of phenotypic plasticity is the bidirectional conversions among epithelial, mesenchymal, and hybrid epithelial/mesenchymal (E/M) phenotype(s). These conversions can alter a repertoire of cellular traits associated with multiple hallmarks of cancer, such as metabolism, immune evasion, invasion, and metastasis. To tackle the complexity and heterogeneity of these transitions, mathematical models have been developed that seek to capture the experimentally verified molecular mechanisms and act as ‘hypothesis-generating machines’. Here, we discuss how these quantitative mathematical models have helped us explain existing experimental data, guided further experiments, and provided an improved conceptual framework for understanding how multiple intracellular and extracellular signals can drive E/M plasticity at both the single-cell and population levels. We also discuss the implications of this plasticity in driving multiple aggressive facets of tumor progression.
dc.identifier.citationJolly, Mohit Kumar, Tripathi, Satyendra C., Somarelli, Jason A., et al.. "Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?." <i>Molecular Oncology,</i> 11, no. 7 (2017) Wiley: 739-754. https://doi.org/10.1002/1878-0261.12084.
dc.identifier.digitalEpithelial_mesenchymal_plasticity
dc.identifier.doihttps://doi.org/10.1002/1878-0261.12084
dc.identifier.urihttps://hdl.handle.net/1911/97371
dc.language.isoeng
dc.publisherWiley
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.keywordcirculating tumor cells
dc.subject.keywordcollective cell migration
dc.subject.keywordepithelial-mesenchymal transition
dc.subject.keywordhybrid epithelial/mesenchymal
dc.subject.keywordmathematical modeling
dc.subject.keywordstemness
dc.titleEpithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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