Detection and characterization of constitutive replication origins defined by DNA polymerase epsilon
| dc.citation.articleNumber | 41 | |
| dc.citation.journalTitle | BMC Biology | |
| dc.citation.volumeNumber | 21 | |
| dc.contributor.author | Jaksik, Roman | |
| dc.contributor.author | Wheeler, David A. | |
| dc.contributor.author | Kimmel, Marek | |
| dc.date.accessioned | 2023-03-10T19:04:19Z | |
| dc.date.available | 2023-03-10T19:04:19Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | Despite the process of DNA replication being mechanistically highly conserved, the location of origins of replication (ORI) may vary from one tissue to the next, or between rounds of replication in eukaryotes, suggesting flexibility in the choice of locations to initiate replication. Lists of human ORI therefore vary widely in number and location, and there are currently no methods available to compare them. Here, we propose a method of detection of ORI based on somatic mutation patterns generated by the mutator phenotype of damaged DNA polymerase epsilon (POLE). | |
| dc.identifier.citation | Jaksik, Roman, Wheeler, David A. and Kimmel, Marek. "Detection and characterization of constitutive replication origins defined by DNA polymerase epsilon." <i>BMC Biology,</i> 21, (2023) Springer Nature: https://doi.org/10.1186/s12915-023-01527-z. | |
| dc.identifier.digital | s12915-023-01527-z | |
| dc.identifier.doi | https://doi.org/10.1186/s12915-023-01527-z | |
| dc.identifier.uri | https://hdl.handle.net/1911/114512 | |
| dc.language.iso | eng | |
| dc.publisher | Springer Nature | |
| dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. | |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/. | |
| dc.title | Detection and characterization of constitutive replication origins defined by DNA polymerase epsilon | |
| dc.type | Journal article | |
| dc.type.dcmi | Text | |
| dc.type.publication | publisher version |
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