CXCL10 is a crucial chemoattractant for efficient intranasal delivery of mesenchymal stem cells to the neonatal hypoxic-ischemic brain

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dc.citation.articleNumber134
dc.citation.issueNumber1
dc.citation.journalTitleStem Cell Research & Therapy
dc.citation.volumeNumber15
dc.contributor.authorHermans, Eva C.
dc.contributor.authorDonega, Vanessa
dc.contributor.authorHeijnen, Cobi J.
dc.contributor.authorde Theije, Caroline G.M.
dc.contributor.authorNijboer, Cora H.
dc.date.accessioned2024-08-02T13:32:11Z
dc.date.available2024-08-02T13:32:11Z
dc.date.issued2024
dc.description.abstractHypoxic-Ischemic Encephalopathy (HIE) is a leading cause of mortality and morbidity in newborns. Recent research has shown promise in using intranasal mesenchymal stem cell (MSC) therapy if administered within 10 days after Hypoxia-Ischemia (HI) in neonatal mice. MSCs migrate from the nasal cavity to the cerebral lesion in response to chemotactic cues. Which exact chemokines are crucial for MSC guidance to the HI lesion is currently not fully understood. This study investigates the role of CXCL10 in MSC migration towards the HI-injured brain.
dc.identifier.citationHermans, E. C., Donega, V., Heijnen, C. J., de Theije, C. G. M., & Nijboer, C. H. (2024). CXCL10 is a crucial chemoattractant for efficient intranasal delivery of mesenchymal stem cells to the neonatal hypoxic-ischemic brain. Stem Cell Research & Therapy, 15(1), 134. https://doi.org/10.1186/s13287-024-03747-8
dc.identifier.digitals13287-024-03747-8
dc.identifier.doihttps://doi.org/10.1186/s13287-024-03747-8
dc.identifier.urihttps://hdl.handle.net/1911/117583
dc.language.isoeng
dc.publisherSpringer Nature
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleCXCL10 is a crucial chemoattractant for efficient intranasal delivery of mesenchymal stem cells to the neonatal hypoxic-ischemic brain
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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