BioSciences faculty publications.
For works published before Summer 2014, please see the Biochemistry & Cell Biology and Ecology & Evolutionary Biology collections.
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Browsing BioSciences Publications by Subject "ab initio phasing"
(International Union of Crystallography, 2016) He, Hongxing; Fang, Hengrui; Miller, Mitchell D.; Phillips, George N.Jr.; Su, Wu-Pei
An iterative transform method proposed previously for direct phasing of high-solvent-content protein crystals is employed for enhancing the molecular-replacement (MR) algorithm in protein crystallography. Target structures that are resistant to conventional MR due to insufficient similarity between the template and target structures might be tractable with this modified phasing method. Trial calculations involving three different structures are described to test and illustrate the methodology. The relationship of the approach toﾠPHENIX Phaser-MRﾠandﾠMR-Rosettaﾠis discussed.