Genomics-aided structure prediction
| dc.citation.firstpage | 10340 | |
| dc.citation.issueNumber | 26 | en_US |
| dc.citation.journalTitle | PNAS | en_US |
| dc.citation.lastpage | 10345 | |
| dc.citation.volumeNumber | 109 | en_US |
| dc.contributor.author | Sulkowska, Joanna I. | |
| dc.contributor.author | Morcos, Faruck | |
| dc.contributor.author | Weigt, Martin | |
| dc.contributor.author | Hwa, Terence | |
| dc.contributor.author | Onuchic, José N. | |
| dc.contributor.funder | National Science Foundation | en_US |
| dc.contributor.org | Center for Theoretical Biological Physics | en_US |
| dc.date.accessioned | 2013-03-14T15:17:54Z | |
| dc.date.available | 2013-03-14T15:17:54Z | |
| dc.date.issued | 2012 | |
| dc.description.abstract | We introduce a theoretical framework that exploits the everincreasing genomic sequence information for protein structure prediction. Structure-based models are modified to incorporate constraints by a large number of non-local contacts estimated from direct coupling analysis (DCA) of co-evolving genomic sequences. A simple hybrid method, called DCA-fold, integrating DCA contacts with an accurate knowledge of local information (e.g., the local secondary structure) is sufficient to fold proteins in the range of 1–3 Å resolution. | en_US |
| dc.embargo.terms | none | en_US |
| dc.identifier.citation | Sulkowska, Joanna I., Morcos, Faruck, Weigt, Martin, et al.. "Genomics-aided structure prediction." <i>PNAS,</i> 109, no. 26 (2012) 10340-10345. http://dx.doi.org/10.1073/pnas.1207864109. | * |
| dc.identifier.doi | http://dx.doi.org/10.1073/pnas.1207864109 | en_US |
| dc.identifier.grantID | PHY-0822283 (National Science Foundation) | |
| dc.identifier.grantID | NSF-MCB-1214457 (National Science Foundation) | |
| dc.identifier.uri | https://hdl.handle.net/1911/70585 | |
| dc.language.iso | eng | en_US |
| dc.subject.keyword | protein folding | en_US |
| dc.subject.keyword | residue contact prediction | en_US |
| dc.subject.keyword | contact map estimation | en_US |
| dc.subject.keyword | residue-residue coevolution | en_US |
| dc.subject.keyword | statistical potentials | en_US |
| dc.title | Genomics-aided structure prediction | en_US |
| dc.type | Journal article | en_US |
| dc.type.dcmi | Text | en_US |