Prostate cancer and neuroendocrine differentiation: more neuronal, less endocrine?

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dc.citation.journalTitleFrontiers in Oncologyen_US
dc.citation.volumeNumber5en_US
dc.contributor.authorGrigore, Alexandru Danen_US
dc.contributor.authorBen-Jacob, Eshelen_US
dc.contributor.authorFarach-Carson, Mary C.en_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2016-03-24T18:24:35Zen_US
dc.date.available2016-03-24T18:24:35Zen_US
dc.date.issued2015en_US
dc.description.abstractNeuroendocrine differentiation (NED) marks a structural and functional feature of certain cancers, including prostate cancer (PCa), whereby the malignant tissue contains a significant proportion of cells displaying neuronal, endocrine, or mixed features. NED cells produce, and can secrete, a cocktail of mediators commonly encountered in the nervous system, which may stimulate and coordinate cancer growth. In PCa, NED appears during advanced stages, subsequent to treatment, and accompanies treatment resistance and poor prognosis. However, the term "neuroendocrine" in this context is intrinsically vague. This article seeks to provide a framework on which a unified view of NED might emerge. First, we review the mutually beneficial interplay between PCa and neural structures, mainly supported by cell biology experiments and neurological conditions. Next, we address the correlations between PCa and neural functions, as described in the literature. Based upon the integration of clinical and basic observations, we suggest that it is legitimate to seek for true neural differentiation, or neuromimicry, in cancer progression, most notably in PCa cells exhibiting what is commonly described as NED.en_US
dc.identifier.citationGrigore, Alexandru Dan, Ben-Jacob, Eshel and Farach-Carson, Mary C.. "Prostate cancer and neuroendocrine differentiation: more neuronal, less endocrine?." <i>Frontiers in Oncology,</i> 5, (2015) Frontiers Media S.A.: http://dx.doi.org/10.3389/fonc.2015.00037.en_US
dc.identifier.doihttp://dx.doi.org/10.3389/fonc.2015.00037en_US
dc.identifier.urihttps://hdl.handle.net/1911/88646en_US
dc.language.isoengen_US
dc.publisherFrontiers Media S.A.en_US
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subject.keywordchromogranin Aen_US
dc.subject.keywordinterleukin-6en_US
dc.subject.keywordneural differentiationen_US
dc.subject.keywordneuroendocrine differentiationen_US
dc.subject.keywordprostate canceren_US
dc.titleProstate cancer and neuroendocrine differentiation: more neuronal, less endocrine?en_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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