Electronic relaxation pathways in thio-acridone and thio-coumarin: two heavy-atom-free photosensitizers absorbing visible light

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dc.citation.firstpage28980en_US
dc.citation.issueNumber46en_US
dc.citation.journalTitlePhysical Chemistry Chemical Physicsen_US
dc.citation.lastpage28991en_US
dc.citation.volumeNumber26en_US
dc.contributor.authorAcquah, Chrisen_US
dc.contributor.authorHoehn, Seanen_US
dc.contributor.authorKrul, Sarahen_US
dc.contributor.authorJockusch, Steffenen_US
dc.contributor.authorYang, Shudanen_US
dc.contributor.authorSeth, Sourav Kantien_US
dc.contributor.authorLee, Ericen_US
dc.contributor.authorXiao, Hanen_US
dc.contributor.authorCrespo-Hernández, Carlos E.en_US
dc.contributor.orgBioengineeringen_US
dc.contributor.orgBiosciencesen_US
dc.contributor.orgChemistryen_US
dc.contributor.orgSynthesis X Centeren_US
dc.date.accessioned2025-01-09T20:17:00Zen_US
dc.date.available2025-01-09T20:17:00Zen_US
dc.date.issued2024en_US
dc.description.abstractHeavy-atom-free photosensitizers (HAF-PSs) have emerged as a new class of photosensitizers aiming to broaden their applicability and versatility across various fields of the photodynamic therapy of cancers. The strategy involves replacing the exocyclic oxygen atoms of the carbonyl groups of established biocompatible organic fluorophores with sulfur, thereby bathochromically shifting their absorption spectra and enhancing their intersystem crossing efficiencies. Despite these advancements, the photophysical attributes and electronic relaxation mechanisms of many of these HAF-PSs remain inadequately elucidated. In this study, we investigate the excited state dynamics and photochemical properties of two promising HAF-PSs, thio-coumarin and thio-acridone. Employing a combination of steady-state and time-resolved techniques from femtoseconds to microseconds, coupled with quantum chemical calculations, we unravel the electronic relaxation mechanisms that give rise to the efficient population of long-lived and reactive triplet states in these HAF-PSs.en_US
dc.identifier.citationAcquah, C., Hoehn, S., Krul, S., Jockusch, S., Yang, S., Kanti Seth, S., Lee, E., Xiao, H., & E. Crespo-Hernández, C. (2024). Electronic relaxation pathways in thio-acridone and thio-coumarin: Two heavy-atom-free photosensitizers absorbing visible light. Physical Chemistry Chemical Physics, 26(46), 28980–28991. https://doi.org/10.1039/D4CP03720Ken_US
dc.identifier.digitald4cp03720ken_US
dc.identifier.doihttps://doi.org/10.1039/D4CP03720Ken_US
dc.identifier.urihttps://hdl.handle.net/1911/118124en_US
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution-NonCommercial (CC BY-NC) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/en_US
dc.titleElectronic relaxation pathways in thio-acridone and thio-coumarin: two heavy-atom-free photosensitizers absorbing visible lighten_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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