Targeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells

Simple item page
dc.citation.firstpage1209en_US
dc.citation.issueNumber8en_US
dc.citation.journalTitleNanomedicineen_US
dc.citation.lastpage1222en_US
dc.citation.volumeNumber9en_US
dc.contributor.authorChen, Wenxueen_US
dc.contributor.authorAyala-Orozco, Ciceronen_US
dc.contributor.authorBiswal, Nrusingh C.en_US
dc.contributor.authorPerez-Torres, Carlosen_US
dc.contributor.authorBartels, Marcen_US
dc.contributor.authorBardhan, Riziaen_US
dc.contributor.authorStinnet, Garyen_US
dc.contributor.authorLiu, Xian-Deen_US
dc.contributor.authorJi, Baoanen_US
dc.contributor.authorDeorukhkar, Amiten_US
dc.contributor.authorBrown, Lisa V.en_US
dc.contributor.authorGuha, Sushovanen_US
dc.contributor.authorPautler, Robia G.en_US
dc.contributor.authorKrishnan, Sunilen_US
dc.contributor.authorHalas, Naomi J.en_US
dc.contributor.authorJoshi, Amiten_US
dc.date.accessioned2017-08-04T12:29:41Zen_US
dc.date.available2017-08-04T12:29:41Zen_US
dc.date.issued2014en_US
dc.description.abstractAim: We report a magneto-fluorescent theranostic nanocomplex targeted to neutrophil gelatinase-associated lipocalin (NGAL) for imaging and therapy of pancreatic cancer. Materials & methods: Gold nanoshells resonant at 810 nm were encapsulated in silica epilayers doped with iron oxide and the near-infrared (NIR) dye indocyanine green, resulting in theranostic gold nanoshells (TGNS), which were subsequently conjugated with antibodies targeting NGAL in AsPC-1-derived xenografts in nude mice. Results: Anti-NGAL-conjugated TGNS specifically targeted pancreatic cancer cells in vitro and in vivo providing contrast for both NIR fluorescence and T2-weighted MRI with higher tumor contrast than can be obtained using long-circulating, but nontargeted, PEGylated nanoparticles. The nanocomplexes also enabled highly specific cancer cell death via NIR photothermal therapy in vitro. Conclusion: TGNS with embedded NIR and magnetic resonance contrasts can be specifically targeted to pancreatic cancer cells with expression of early disease marker NGAL, and enable molecularly targeted imaging and photothermal therapy.en_US
dc.identifier.citationChen, Wenxue, Ayala-Orozco, Ciceron, Biswal, Nrusingh C., et al.. "Targeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells." <i>Nanomedicine,</i> 9, no. 8 (2014) Future Medicine: 1209-1222. https://doi.org/10.2217/nnm.13.84.en_US
dc.identifier.digitalTargeting_Pancreatic_Canceren_US
dc.identifier.doihttps://doi.org/10.2217/nnm.13.84en_US
dc.identifier.urihttps://hdl.handle.net/1911/96576en_US
dc.language.isoengen_US
dc.publisherFuture Medicineen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Future Science Groupen_US
dc.subject.keywordMRIen_US
dc.subject.keywordnanoshellsen_US
dc.subject.keywordnoninvasive imagingen_US
dc.subject.keywordoptical imagingen_US
dc.subject.keywordpancreatic canceren_US
dc.subject.keywordphotothermalen_US
dc.titleTargeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshellsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Targeting_Pancreatic_Cancer.pdf
Size:
3.16 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Chemistry Publications
ECE Publications