Targeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells

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dc.citation.firstpage1209
dc.citation.issueNumber8
dc.citation.journalTitleNanomedicine
dc.citation.lastpage1222
dc.citation.volumeNumber9
dc.contributor.authorChen, Wenxue
dc.contributor.authorAyala-Orozco, Ciceron
dc.contributor.authorBiswal, Nrusingh C.
dc.contributor.authorPerez-Torres, Carlos
dc.contributor.authorBartels, Marc
dc.contributor.authorBardhan, Rizia
dc.contributor.authorStinnet, Gary
dc.contributor.authorLiu, Xian-De
dc.contributor.authorJi, Baoan
dc.contributor.authorDeorukhkar, Amit
dc.contributor.authorBrown, Lisa V.
dc.contributor.authorGuha, Sushovan
dc.contributor.authorPautler, Robia G.
dc.contributor.authorKrishnan, Sunil
dc.contributor.authorHalas, Naomi J.
dc.contributor.authorJoshi, Amit
dc.date.accessioned2017-08-04T12:29:41Z
dc.date.available2017-08-04T12:29:41Z
dc.date.issued2014
dc.description.abstractAim: We report a magneto-fluorescent theranostic nanocomplex targeted to neutrophil gelatinase-associated lipocalin (NGAL) for imaging and therapy of pancreatic cancer. Materials & methods: Gold nanoshells resonant at 810 nm were encapsulated in silica epilayers doped with iron oxide and the near-infrared (NIR) dye indocyanine green, resulting in theranostic gold nanoshells (TGNS), which were subsequently conjugated with antibodies targeting NGAL in AsPC-1-derived xenografts in nude mice. Results: Anti-NGAL-conjugated TGNS specifically targeted pancreatic cancer cells in vitro and in vivo providing contrast for both NIR fluorescence and T2-weighted MRI with higher tumor contrast than can be obtained using long-circulating, but nontargeted, PEGylated nanoparticles. The nanocomplexes also enabled highly specific cancer cell death via NIR photothermal therapy in vitro. Conclusion: TGNS with embedded NIR and magnetic resonance contrasts can be specifically targeted to pancreatic cancer cells with expression of early disease marker NGAL, and enable molecularly targeted imaging and photothermal therapy.
dc.identifier.citationChen, Wenxue, Ayala-Orozco, Ciceron, Biswal, Nrusingh C., et al.. "Targeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells." <i>Nanomedicine,</i> 9, no. 8 (2014) Future Medicine: 1209-1222. https://doi.org/10.2217/nnm.13.84.
dc.identifier.digitalTargeting_Pancreatic_Cancer
dc.identifier.doihttps://doi.org/10.2217/nnm.13.84
dc.identifier.urihttps://hdl.handle.net/1911/96576
dc.language.isoeng
dc.publisherFuture Medicine
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Future Science Group
dc.subject.keywordMRI
dc.subject.keywordnanoshells
dc.subject.keywordnoninvasive imaging
dc.subject.keywordoptical imaging
dc.subject.keywordpancreatic cancer
dc.subject.keywordphotothermal
dc.titleTargeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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