On the Reproducibility of TCGA Ovarian Cancer MicroRNA Profiles

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dc.citation.firstpagee87782en_US
dc.citation.issueNumber1en_US
dc.citation.journalTitlePLoS ONEen_US
dc.citation.volumeNumber9en_US
dc.contributor.authorWan, Ying-Wooien_US
dc.contributor.authorMach, Claire M.en_US
dc.contributor.authorAllen, Genevera I.en_US
dc.contributor.authorAnderson, Matthew L.en_US
dc.contributor.authorLiu, Zhandongen_US
dc.date.accessioned2014-10-08T21:25:37Zen_US
dc.date.available2014-10-08T21:25:37Zen_US
dc.date.issued2014en_US
dc.description.abstractDysregulated microRNA (miRNA) expression is a well-established feature of human cancer. However, the role of specific miRNAs in determining cancer outcomes remains unclear. Using Level 3 expression data from the Cancer Genome Atlas (TCGA), we identified 61 miRNAs that are associated with overall survival in 469 ovarian cancers profiled by microarray (p<0.01). We also identified 12 miRNAs that are associated with survival when miRNAs were profiled in the same specimens using Next Generation Sequencing (miRNA-Seq) (p<0.01). Surprisingly, only 1 miRNA transcript is associated with ovarian cancer survival in both datasets. Our analyses indicate that this discrepancy is due to the fact that miRNA levels reported by the two platforms correlate poorly, even after correcting for potential issues inherent to signal detection algorithms. Corrections for false discovery and microRNA abundance had minimal impact on this discrepancy. Further investigation is warranted.en_US
dc.identifier.citationWan, Ying-Wooi, Mach, Claire M., Allen, Genevera I., et al.. "On the Reproducibility of TCGA Ovarian Cancer MicroRNA Profiles." <i>PLoS ONE,</i> 9, no. 1 (2014) Public Library of Science: e87782. http://dx.doi.org/10.1371/journal.pone.0087782.en_US
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0087782en_US
dc.identifier.urihttps://hdl.handle.net/1911/77458en_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleOn the Reproducibility of TCGA Ovarian Cancer MicroRNA Profilesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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