Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions

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dc.citation.articleNumber106232
dc.citation.journalTitleOral Oncology
dc.citation.volumeNumber135
dc.contributor.authorBrenes, David R.
dc.contributor.authorNipper, Allison J.
dc.contributor.authorTan, Melody T.
dc.contributor.authorGleber-Netto, Frederico O.
dc.contributor.authorSchwarz, Richard A.
dc.contributor.authorPickering, Curtis R.
dc.contributor.authorWilliams, Michelle D.
dc.contributor.authorVigneswaran, Nadarajah
dc.contributor.authorGillenwater, Ann M.
dc.contributor.authorSikora, Andrew G.
dc.contributor.authorRichards-Kortum, Rebecca R.
dc.date.accessioned2022-12-13T19:11:05Z
dc.date.available2022-12-13T19:11:05Z
dc.date.issued2022
dc.description.abstractObjective Optical imaging studies of oral premalignant lesions have shown that optical markers, including loss of autofluorescence and altered morphology of epithelial cell nuclei, are predictive of high-grade pathology. While these optical markers are consistently positive in lesions with moderate/severe dysplasia or cancer, they are positive only in a subset of lesions with mild dysplasia. This study compared the gene expression profiles of lesions with mild dysplasia (stratified by optical marker status) to lesions with severe dysplasia and without dysplasia. Materials and methods Forty oral lesions imaged in patients undergoing oral surgery were analyzed: nine without dysplasia, nine with severe dysplasia, and 22 with mild dysplasia. Samples were submitted for high throughput gene expression analysis. Results The analysis revealed 116 genes differentially expressed among sites without dysplasia and sites with severe dysplasia; 50 were correlated with an optical marker quantifying altered nuclear morphology. Ten of 11 sites with mild dysplasia and positive optical markers (91%) had gene expression similar to sites with severe dysplasia. Nine of 11 sites with mild dysplasia and negative optical markers (82%) had similar gene expression as sites without dysplasia. Conclusion This study suggests that optical imaging may help identify patients with mild dysplasia who require more intensive clinical follow-up. If validated, this would represent a significant advance in patient care for patients with oral premalignant lesions.
dc.identifier.citationBrenes, David R., Nipper, Allison J., Tan, Melody T., et al.. "Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions." <i>Oral Oncology,</i> 135, (2022) Elsevier: https://doi.org/10.1016/j.oraloncology.2022.106232.
dc.identifier.digital1-s2-0-S1368837522005218-main
dc.identifier.doihttps://doi.org/10.1016/j.oraloncology.2022.106232
dc.identifier.urihttps://hdl.handle.net/1911/114076
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/bync-nd/4.0/).
dc.titleMildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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