Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions

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dc.citation.articleNumber106232en_US
dc.citation.journalTitleOral Oncologyen_US
dc.citation.volumeNumber135en_US
dc.contributor.authorBrenes, David R.en_US
dc.contributor.authorNipper, Allison J.en_US
dc.contributor.authorTan, Melody T.en_US
dc.contributor.authorGleber-Netto, Frederico O.en_US
dc.contributor.authorSchwarz, Richard A.en_US
dc.contributor.authorPickering, Curtis R.en_US
dc.contributor.authorWilliams, Michelle D.en_US
dc.contributor.authorVigneswaran, Nadarajahen_US
dc.contributor.authorGillenwater, Ann M.en_US
dc.contributor.authorSikora, Andrew G.en_US
dc.contributor.authorRichards-Kortum, Rebecca R.en_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2022-12-13T19:11:05Zen_US
dc.date.available2022-12-13T19:11:05Zen_US
dc.date.issued2022en_US
dc.description.abstractObjective Optical imaging studies of oral premalignant lesions have shown that optical markers, including loss of autofluorescence and altered morphology of epithelial cell nuclei, are predictive of high-grade pathology. While these optical markers are consistently positive in lesions with moderate/severe dysplasia or cancer, they are positive only in a subset of lesions with mild dysplasia. This study compared the gene expression profiles of lesions with mild dysplasia (stratified by optical marker status) to lesions with severe dysplasia and without dysplasia. Materials and methods Forty oral lesions imaged in patients undergoing oral surgery were analyzed: nine without dysplasia, nine with severe dysplasia, and 22 with mild dysplasia. Samples were submitted for high throughput gene expression analysis. Results The analysis revealed 116 genes differentially expressed among sites without dysplasia and sites with severe dysplasia; 50 were correlated with an optical marker quantifying altered nuclear morphology. Ten of 11 sites with mild dysplasia and positive optical markers (91%) had gene expression similar to sites with severe dysplasia. Nine of 11 sites with mild dysplasia and negative optical markers (82%) had similar gene expression as sites without dysplasia. Conclusion This study suggests that optical imaging may help identify patients with mild dysplasia who require more intensive clinical follow-up. If validated, this would represent a significant advance in patient care for patients with oral premalignant lesions.en_US
dc.identifier.citationBrenes, David R., Nipper, Allison J., Tan, Melody T., et al.. "Mildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesions." <i>Oral Oncology,</i> 135, (2022) Elsevier: https://doi.org/10.1016/j.oraloncology.2022.106232.en_US
dc.identifier.digital1-s2-0-S1368837522005218-mainen_US
dc.identifier.doihttps://doi.org/10.1016/j.oraloncology.2022.106232en_US
dc.identifier.urihttps://hdl.handle.net/1911/114076en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).en_US
dc.rights.urihttp://creativecommons.org/licenses/bync-nd/4.0/).en_US
dc.titleMildly dysplastic oral lesions with optically-detectable abnormalities share genetic similarities with severely dysplastic lesionsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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