Influence of decoys on the noise and dynamics of gene expression

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dc.citation.articleNumber41920
dc.citation.issueNumber4
dc.citation.journalTitlePhysical Review E
dc.citation.volumeNumber86
dc.contributor.authorBurger, Anat
dc.contributor.authorWalczak, Aleksandra M.
dc.contributor.authorWolynes, Peter G.
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2017-08-02T14:52:15Z
dc.date.available2017-08-02T14:52:15Z
dc.date.issued2012
dc.description.abstractMany transcription factors bind to DNA with a remarkable lack of specificity, so that regulatory binding sites compete with an enormous number of nonregulatory “decoy” sites. For an autoregulated gene, we show decoy sites decrease noise in the number of unbound proteins to a Poisson limit that results from binding and unbinding. This noise buffering is optimized for a given protein concentration when decoys have a 1/2 probability of being occupied. Decoys linearly increase the time to approach steady state and exponentially increase the time to switch epigenetically between bistable states.
dc.identifier.citationBurger, Anat, Walczak, Aleksandra M. and Wolynes, Peter G.. "Influence of decoys on the noise and dynamics of gene expression." <i>Physical Review E,</i> 86, no. 4 (2012) American Physical Society: https://doi.org/10.1103/PhysRevE.86.041920.
dc.identifier.digitalInfluence_decoys_noise_dynamics_gene_expression
dc.identifier.doihttps://doi.org/10.1103/PhysRevE.86.041920
dc.identifier.urihttps://hdl.handle.net/1911/96163
dc.language.isoeng
dc.publisherAmerican Physical Society
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.titleInfluence of decoys on the noise and dynamics of gene expression
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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