Heat shock factor 1 (HSF1) cooperates with estrogen receptor α (ERα) in the regulation of estrogen action in breast cancer cells

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dc.citation.articleNumbere69843
dc.citation.journalTitleeLife
dc.citation.volumeNumber10
dc.contributor.authorVydra, Natalia
dc.contributor.authorJanus, Patryk
dc.contributor.authorKus, Paweł
dc.contributor.authorStokowy, Tomasz
dc.contributor.authorMrowiec, Katarzyna
dc.contributor.authorToma-Jonik, Agnieszka
dc.contributor.authorKrzywon, Aleksandra
dc.contributor.authorCortez, Alexander Jorge
dc.contributor.authorWojtas, Bartosz
dc.contributor.authorGielniewski, Bartłomiej
dc.contributor.authorJaksik, Roman
dc.contributor.authorKimmel, Marek
dc.contributor.authorWidlak, Wieslawa
dc.date.accessioned2022-01-27T20:24:12Z
dc.date.available2022-01-27T20:24:12Z
dc.date.issued2021
dc.description.abstractHeat shock factor 1 (HSF1), a key regulator of transcriptional responses to proteotoxic stress, was linked to estrogen (E2) signaling through estrogen receptor α (ERα). We found that an HSF1 deficiency may decrease ERα level, attenuate the mitogenic action of E2, counteract E2-stimulated cell scattering, and reduce adhesion to collagens and cell motility in ER-positive breast cancer cells. The stimulatory effect of E2 on the transcriptome is largely weaker in HSF1-deficient cells, in part due to the higher basal expression of E2-dependent genes, which correlates with the enhanced binding of unliganded ERα to chromatin in such cells. HSF1 and ERα can cooperate directly in E2-stimulated regulation of transcription, and HSF1 potentiates the action of ERα through a mechanism involving chromatin reorganization. Furthermore, HSF1 deficiency may increase the sensitivity to hormonal therapy (4-hydroxytamoxifen) or CDK4/6 inhibitors (palbociclib). Analyses of data from The Cancer Genome Atlas database indicate that HSF1 increases the transcriptome disparity in ER-positive breast cancer and can enhance the genomic action of ERα. Moreover, only in ER-positive cancers an elevated HSF1 level is associated with metastatic disease.
dc.identifier.citationVydra, Natalia, Janus, Patryk, Kus, Paweł, et al.. "Heat shock factor 1 (HSF1) cooperates with estrogen receptor α (ERα) in the regulation of estrogen action in breast cancer cells." <i>eLife,</i> 10, (2021) eLife Sciences Publications Ltd: https://doi.org/10.7554/eLife.69843.
dc.identifier.digitalelife-69843-v2
dc.identifier.doihttps://doi.org/10.7554/eLife.69843
dc.identifier.urihttps://hdl.handle.net/1911/111953
dc.language.isoeng
dc.publishereLife Sciences Publications Ltd
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleHeat shock factor 1 (HSF1) cooperates with estrogen receptor α (ERα) in the regulation of estrogen action in breast cancer cells
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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