Alpha-hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of alpha subunits of human HbA with hydrogen peroxide
| dc.citation.journalTitle | Journal of Biological Chemistry | en_US |
| dc.contributor.author | Mollan, Todd L. | en_US |
| dc.contributor.author | Banerjee, Sambuddha | en_US |
| dc.contributor.author | Wu, Gang | en_US |
| dc.contributor.author | Siburt, Claire J.Parker | en_US |
| dc.contributor.author | Tsai, Ah-Lim | en_US |
| dc.contributor.author | Olson, John S. | en_US |
| dc.contributor.author | Weiss, Mitchell J. | en_US |
| dc.contributor.author | Crumbliss, Alvin L. | en_US |
| dc.contributor.author | Alayash, Abdu I. | en_US |
| dc.date.accessioned | 2013-02-01T17:33:47Z | en_US |
| dc.date.available | 2014-02-02T06:10:03Z | en_US |
| dc.date.issued | 2012 | en_US |
| dc.description.abstract | Background: AHSP modifies redox properties of bound α subunits. Results: Isolated hemoglobin subunits exhibit significantly different redox properties compared to HbA. A significant decrease in the reduction potential of α subunits bound to AHSP results in preferential binding of ferric α. Conclusion: AHSP:α subunit complexes do not participate in ferric-ferryl heme redox cycling. Significance: AHSP binding to α subunits inhibits subunit pseudoperoxidase activity. | en_US |
| dc.embargo.terms | 1 year | en_US |
| dc.identifier.citation | Mollan, Todd L., Banerjee, Sambuddha, Wu, Gang, et al.. "Alpha-hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of alpha subunits of human HbA with hydrogen peroxide." <i>Journal of Biological Chemistry,</i> (2012) The American Society for Biochemistry and Molecular Biology, Inc.: http://dx.doi.org/10.1074/jbc.M112.412064. | en_US |
| dc.identifier.doi | http://dx.doi.org/10.1074/jbc.M112.412064 | en_US |
| dc.identifier.uri | https://hdl.handle.net/1911/69913 | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | The American Society for Biochemistry and Molecular Biology, Inc. | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.title | Alpha-hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of alpha subunits of human HbA with hydrogen peroxide | en_US |
| dc.type | Journal article | en_US |
| dc.type.dcmi | Text | en_US |
| dc.type.publication | publisher version | en_US |