Encryption of adeno-associated viruses with enzymatically decoded peptide locks

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dc.contributor.assigneeRice University
dc.contributor.publisherUnited States Patent and Trademark Office
dc.creatorJudd, Justin
dc.creatorSuh, Junghae
dc.creatorSilberg, Jonathan
dc.date.accessioned2019-02-22T15:19:38Z
dc.date.available2019-02-22T15:19:38Z
dc.date.filed2013-04-29
dc.date.issued2018-08-14
dc.description.abstractThe present invention is a peptide lock that comprises at least one peptide that is genetically encoded into the Adeno-associated virus (AAV) capsid that block biologically active domains on the virus capsid surface. The peptide lock, can be processed by biological enzymes to restore biological behavior of the capsid-displayed domains, thus ‘decoding the lock’ or opening the lock. A method of forming the peptide lock comprises providing at least one peptide, providing an Adeno-associated virus capsid and genetically inserting the at least one peptide into the Adeno-associated virus capsid to block the biologically active domains on the virus capsid surface.
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes
dc.format.extent27
dc.identifier.citationJudd, Justin, Suh, Junghae and Silberg, Jonathan, "Encryption of adeno-associated viruses with enzymatically decoded peptide locks." Patent US10047128B2. issued 2018-08-14. Retrieved from <a href="https://hdl.handle.net/1911/105159">https://hdl.handle.net/1911/105159</a>.
dc.identifier.patentIDUS10047128B2
dc.identifier.urihttps://hdl.handle.net/1911/105159
dc.language.isoeng
dc.titleEncryption of adeno-associated viruses with enzymatically decoded peptide locks
dc.typeUtility patent
dc.type.dcmiText
dc.type.genrepatents
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