Encryption of adeno-associated viruses with enzymatically decoded peptide locks

Simple item page
dc.contributor.assigneeRice Universityen_US
dc.contributor.publisherUnited States Patent and Trademark Officeen_US
dc.creatorJudd, Justinen_US
dc.creatorSuh, Junghaeen_US
dc.creatorSilberg, Jonathanen_US
dc.date.accessioned2019-02-22T15:19:38Zen_US
dc.date.available2019-02-22T15:19:38Zen_US
dc.date.filed2013-04-29en_US
dc.date.issued2018-08-14en_US
dc.description.abstractThe present invention is a peptide lock that comprises at least one peptide that is genetically encoded into the Adeno-associated virus (AAV) capsid that block biologically active domains on the virus capsid surface. The peptide lock, can be processed by biological enzymes to restore biological behavior of the capsid-displayed domains, thus ‘decoding the lock’ or opening the lock. A method of forming the peptide lock comprises providing at least one peptide, providing an Adeno-associated virus capsid and genetically inserting the at least one peptide into the Adeno-associated virus capsid to block the biologically active domains on the virus capsid surface.en_US
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposesen_US
dc.format.extent27en_US
dc.identifier.citationJudd, Justin, Suh, Junghae and Silberg, Jonathan, "Encryption of adeno-associated viruses with enzymatically decoded peptide locks." Patent US10047128B2. issued 2018-08-14. Retrieved from <a href="https://hdl.handle.net/1911/105159">https://hdl.handle.net/1911/105159</a>.en_US
dc.identifier.patentIDUS10047128B2en_US
dc.identifier.urihttps://hdl.handle.net/1911/105159en_US
dc.language.isoengen_US
dc.titleEncryption of adeno-associated viruses with enzymatically decoded peptide locksen_US
dc.typeUtility patenten_US
dc.type.dcmiTexten_US
dc.type.genrepatentsen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
US10047128B2.pdf
Size:
1019.56 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Rice Patents