Application of Hydrogels in Heart Valve Tissue Engineering

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dc.citation.firstpage105en_US
dc.citation.issueNumber1-2en_US
dc.citation.journalTitleJournal of Long-Term Effects of Medical Implantsen_US
dc.citation.lastpage134en_US
dc.citation.volumeNumber25en_US
dc.contributor.authorZhang, Xingen_US
dc.contributor.authorXu, Binen_US
dc.contributor.authorPuperi, Daniel S.en_US
dc.contributor.authorWu, Yanen_US
dc.contributor.authorWest, Jennifer L.en_US
dc.contributor.authorGrande-Allen, K. Janeen_US
dc.date.accessioned2016-06-22T16:28:31Zen_US
dc.date.available2016-06-22T16:28:31Zen_US
dc.date.issued2015en_US
dc.description.abstractWith an increasing number of patients requiring valve replacements, there is heightened interest in advancing heart valve tissue engineering (HVTE) to provide solutions to the many limitations of current surgical treatments. A variety of materials have been developed as scaffolds for HVTE including natural polymers, synthetic polymers, and decellularized valvular matrices. Among them, biocompatible hydrogels are generating growing interest. Natural hydrogels, such as collagen and fibrin, generally show good bioactivity but poor mechanical durability. Synthetic hydrogels, on the other hand, have tunable mechanical properties; however, appropriate cell-matrix interactions are difficult to obtain. Moreover, hydrogels can be used as cell carriers when the cellular component is seeded into the polymer meshes or decellularized valve scaffolds. In this review, we discuss current research strategies for HVTE with an emphasis on hydrogel applications. The physicochemical properties and fabrication methods of these hydrogels, as well as their mechanical properties and bioactivities are described. Performance of some hydrogels including in vitro evaluation using bioreactors and in vivo tests in different animal models are also discussed. For future HVTE, it will be compelling to examine how hydrogels can be constructed from composite materials to replicate mechanical properties and mimic biological functions of the native heart valve.en_US
dc.identifier.citationZhang, Xing, Xu, Bin, Puperi, Daniel S., et al.. "Application of Hydrogels in Heart Valve Tissue Engineering." <i>Journal of Long-Term Effects of Medical Implants,</i> 25, no. 1-2 (2015) Begell House: 105-134. http://dx.doi.org/10.1615/JLongTermEffMedImplants.2015011817.en_US
dc.identifier.doihttp://dx.doi.org/10.1615/JLongTermEffMedImplants.2015011817en_US
dc.identifier.urihttps://hdl.handle.net/1911/90520en_US
dc.language.isoengen_US
dc.publisherBegell Houseen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Begell House.en_US
dc.subject.keywordtissue engineeringen_US
dc.subject.keywordhydrogelsen_US
dc.subject.keywordscaffoldsen_US
dc.subject.keywordheart valveen_US
dc.subject.keyworddecellularizationen_US
dc.titleApplication of Hydrogels in Heart Valve Tissue Engineeringen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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