Hierarchically Engineered Artificial Lamellar Bone with High Strength and Toughness

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dc.citation.articleNumber2200256en_US
dc.citation.issueNumber3en_US
dc.citation.journalTitleSmall Structuresen_US
dc.citation.volumeNumber4en_US
dc.contributor.authorZhao, Yonggangen_US
dc.contributor.authorZheng, Jingchuanen_US
dc.contributor.authorXiong, Yangen_US
dc.contributor.authorWang, Hetongen_US
dc.contributor.authorYang, Shuhuien_US
dc.contributor.authorSun, Xiaodanen_US
dc.contributor.authorZhao, Lingyunen_US
dc.contributor.authorMikos, Antonios G.en_US
dc.contributor.authorWang, Xiumeien_US
dc.date.accessioned2024-05-03T15:51:01Zen_US
dc.date.available2024-05-03T15:51:01Zen_US
dc.date.issued2023en_US
dc.description.abstractComplex hierarchical architectures are ubiquitous in natural hard tissues, which comprise an elaborate assembly of hard and soft phases spanning from the nanoscale to the macroscale. The elegant architectures grant unique performance in terms of strength and toughness, but the biomimetic fabrication of synthetic materials with highly consistent structural and mechanical characteristics with natural counterparts remains a great challenge. Here, a centimeter-size artificial lamellar bone is successfully fabricated for the first time via a well-orchestrated “multiscale cascade regulation” strategy combining multiple techniques of molecular self-assembly, electrospinning, and pressure-driven fusion from molecular to macroscopic levels. The bulk artificial lamellar bone that is composed of hierarchically assembled mineralized collagen fibrils with a waiver of any synthetic polymer highly resembles the chemical composition, multiscale structural organization, and rotated plywood-like structure of natural lamellae, thus achieving a good combination of lightweight and high-stiffness (Ey ≈ 15.2 GPa), -strength (σf ≈ 118.4 MPa), and -toughness (KJC ≈ 9.3 MPa m1/2). This multiscale cascade regulation strategy can break through the limitations of a single technique and enable the construction of elaborate composite materials with multiscale step-by-step regulations of hierarchically structural organizations for unique mechanical properties.en_US
dc.identifier.citationZhao, Y., Zheng, J., Xiong, Y., Wang, H., Yang, S., Sun, X., Zhao, L., Mikos, A. G., & Wang, X. (2023). Hierarchically Engineered Artificial Lamellar Bone with High Strength and Toughness. Small Structures, 4(3), 2200256. https://doi.org/10.1002/sstr.202200256en_US
dc.identifier.digitalHierarchicallyEngineeredArtificialLamellarBoneen_US
dc.identifier.doihttps://doi.org/10.1002/sstr.202200256en_US
dc.identifier.urihttps://hdl.handle.net/1911/115498en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleHierarchically Engineered Artificial Lamellar Bone with High Strength and Toughnessen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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