Hierarchically Engineered Artificial Lamellar Bone with High Strength and Toughness

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dc.citation.articleNumber2200256
dc.citation.issueNumber3
dc.citation.journalTitleSmall Structures
dc.citation.volumeNumber4
dc.contributor.authorZhao, Yonggang
dc.contributor.authorZheng, Jingchuan
dc.contributor.authorXiong, Yang
dc.contributor.authorWang, Hetong
dc.contributor.authorYang, Shuhui
dc.contributor.authorSun, Xiaodan
dc.contributor.authorZhao, Lingyun
dc.contributor.authorMikos, Antonios G.
dc.contributor.authorWang, Xiumei
dc.date.accessioned2024-05-03T15:51:01Z
dc.date.available2024-05-03T15:51:01Z
dc.date.issued2023
dc.description.abstractComplex hierarchical architectures are ubiquitous in natural hard tissues, which comprise an elaborate assembly of hard and soft phases spanning from the nanoscale to the macroscale. The elegant architectures grant unique performance in terms of strength and toughness, but the biomimetic fabrication of synthetic materials with highly consistent structural and mechanical characteristics with natural counterparts remains a great challenge. Here, a centimeter-size artificial lamellar bone is successfully fabricated for the first time via a well-orchestrated “multiscale cascade regulation” strategy combining multiple techniques of molecular self-assembly, electrospinning, and pressure-driven fusion from molecular to macroscopic levels. The bulk artificial lamellar bone that is composed of hierarchically assembled mineralized collagen fibrils with a waiver of any synthetic polymer highly resembles the chemical composition, multiscale structural organization, and rotated plywood-like structure of natural lamellae, thus achieving a good combination of lightweight and high-stiffness (Ey ≈ 15.2 GPa), -strength (σf ≈ 118.4 MPa), and -toughness (KJC ≈ 9.3 MPa m1/2). This multiscale cascade regulation strategy can break through the limitations of a single technique and enable the construction of elaborate composite materials with multiscale step-by-step regulations of hierarchically structural organizations for unique mechanical properties.
dc.identifier.citationZhao, Y., Zheng, J., Xiong, Y., Wang, H., Yang, S., Sun, X., Zhao, L., Mikos, A. G., & Wang, X. (2023). Hierarchically Engineered Artificial Lamellar Bone with High Strength and Toughness. Small Structures, 4(3), 2200256. https://doi.org/10.1002/sstr.202200256
dc.identifier.digitalHierarchicallyEngineeredArtificialLamellarBone
dc.identifier.doihttps://doi.org/10.1002/sstr.202200256
dc.identifier.urihttps://hdl.handle.net/1911/115498
dc.language.isoeng
dc.publisherWiley
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleHierarchically Engineered Artificial Lamellar Bone with High Strength and Toughness
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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