Tubulysin analogues as anticancer agents and payloads for antibody-drug conjugates and methods of treatment therewith

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dc.contributor.assigneeRice Universityen_US
dc.contributor.publisherUnited States Patent and Trademark Officeen_US
dc.creatorNicolaou, Kyriacos C.en_US
dc.creatorErande, Rohan Dilipraoen_US
dc.creatorVourloumis, Dionisiosen_US
dc.creatorPulukuri, Kiran Kumaren_US
dc.creatorRigol, Stephanen_US
dc.date.accessioned2022-04-01T16:07:46Zen_US
dc.date.available2022-04-01T16:07:46Zen_US
dc.date.filed2018-11-28en_US
dc.date.issued2022-03-15en_US
dc.description.abstractIn one aspect, the present disclosure provides tubulysin analogs of the formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided.en_US
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes.en_US
dc.format.extent182en_US
dc.identifier.citationNicolaou, Kyriacos C., Erande, Rohan Diliprao, Vourloumis, Dionisios, Pulukuri, Kiran Kumar and Rigol, Stephan, "Tubulysin analogues as anticancer agents and payloads for antibody-drug conjugates and methods of treatment therewith." Patent US11274124B2. issued 2022-03-15. Retrieved from <a href="https://hdl.handle.net/1911/112067">https://hdl.handle.net/1911/112067</a>.en_US
dc.identifier.patentIDUS11274124B2en_US
dc.identifier.urihttps://hdl.handle.net/1911/112067en_US
dc.language.isoengen_US
dc.language.isoEnglishen_US
dc.titleTubulysin analogues as anticancer agents and payloads for antibody-drug conjugates and methods of treatment therewithen_US
dc.typeUtility patenten_US
dc.type.dcmiTexten_US
dc.type.genrepatentsen_US
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