Inclusion of Muscle Forces Affects Finite Element Prediction of Compression Screw Pullout but Not Fatigue Failure in a Custom Pelvic Implant

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dc.citation.articleNumber10396en_US
dc.citation.issueNumber22en_US
dc.citation.journalTitleApplied Sciencesen_US
dc.citation.volumeNumber14en_US
dc.contributor.authorZhu, Yuhuien_US
dc.contributor.authorBabazadeh-Naseri, Ataen_US
dc.contributor.authorBrake, Matthew R. W.en_US
dc.contributor.authorAkin, John E.en_US
dc.contributor.authorLi, Gengen_US
dc.contributor.authorLewis, Valerae O.en_US
dc.contributor.authorFregly, Benjamin J.en_US
dc.date.accessioned2025-01-09T20:16:59Zen_US
dc.date.available2025-01-09T20:16:59Zen_US
dc.date.issued2024en_US
dc.description.abstractCustom implants used for pelvic reconstruction in pelvic sarcoma surgery face a high complication rate due to mechanical failures of fixation screws. Consequently, patient-specific finite element (FE) models have been employed to analyze custom pelvic implant durability. However, muscle forces have often been omitted from FE studies of the post-operative pelvis with a custom implant, despite the lack of evidence that this omission has minimal impact on predicted bone, implant, and fixation screw stress distributions. This study investigated the influence of muscle forces on FE predictions of fixation screw pullout and fatigue failure in a custom pelvic implant. Specifically, FE analyses were conducted using a patient-specific FE model loaded with seven sets of personalized muscle and hip joint contact force loading conditions estimated using a personalized neuromusculoskeletal (NMS) model. Predictions of fixation screw pullout and fatigue failure—quantified by simulated screw axial forces and von Mises stresses, respectively—were compared between analyses with and without personalized muscle forces. The study found that muscle forces had a considerable influence on predicted screw pullout but not fatigue failure. However, it remains unclear whether including or excluding muscle forces would yield more conservative predictions of screw failures. Furthermore, while the effect of muscle forces on predicted screw failures was location-dependent for cortical screws, no clear location dependency was observed for cancellous screws. These findings support the combined use of patient-specific FE and NMS models, including loading from muscle forces, when predicting screw pullout but not fatigue failure in custom pelvic implants.en_US
dc.identifier.citationZhu, Y., Babazadeh-Naseri, A., Brake, M. R. W., Akin, J. E., Li, G., Lewis, V. O., & Fregly, B. J. (2024). Inclusion of Muscle Forces Affects Finite Element Prediction of Compression Screw Pullout but Not Fatigue Failure in a Custom Pelvic Implant. Applied Sciences, 14(22), Article 22. https://doi.org/10.3390/app142210396en_US
dc.identifier.digitalapplsci-14-10396en_US
dc.identifier.doihttps://doi.org/10.3390/app142210396en_US
dc.identifier.urihttps://hdl.handle.net/1911/118119en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subject.keywordcustom pelvic implanten_US
dc.subject.keywordcustom prosthesis designen_US
dc.subject.keywordfinite element analysisen_US
dc.subject.keywordscrew fixation durabilityen_US
dc.subject.keywordscrew failureen_US
dc.titleInclusion of Muscle Forces Affects Finite Element Prediction of Compression Screw Pullout but Not Fatigue Failure in a Custom Pelvic Implanten_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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