Sequence heterogeneity accelerates protein search for targets on DNA

dc.citation.articleNumber245101en_US
dc.citation.issueNumber24en_US
dc.citation.journalTitleThe Journal of Chemical Physicsen_US
dc.citation.volumeNumber143en_US
dc.contributor.authorShvets, Alexey A.en_US
dc.contributor.authorKolomeisky, Anatoly B.en_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2017-05-09T20:16:06Z
dc.date.available2017-05-09T20:16:06Z
dc.date.issued2016en_US
dc.description.abstractThe process of protein search for specific binding sites on DNA is fundamentally important since it marks the beginning of all major biological processes. We present a theoretical investigation that probes the role of DNA sequence symmetry, heterogeneity, and chemical composition in the protein search dynamics. Using a discrete-state stochastic approach with a first-passage events analysis, which takes into account the most relevant physical-chemical processes, a full analytical description of the search dynamics is obtained. It is found that, contrary to existing views, the protein search is generally faster on DNA with more heterogeneous sequences. In addition, the search dynamics might be affected by the chemical composition near the target site. The physical origins of these phenomena are discussed. Our results suggest that biological processes might be effectively regulated by modifying chemical composition, symmetry, and heterogeneity of a genome.en_US
dc.identifier.citationShvets, Alexey A. and Kolomeisky, Anatoly B.. "Sequence heterogeneity accelerates protein search for targets on DNA." <i>The Journal of Chemical Physics,</i> 143, no. 24 (2016) AIP Publishing LLC: http://dx.doi.org/10.1063/1.4937938.
dc.identifier.doihttp://dx.doi.org/10.1063/1.4937938en_US
dc.identifier.urihttps://hdl.handle.net/1911/94209
dc.language.isoengen_US
dc.publisherAIP Publishing LLC
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.titleSequence heterogeneity accelerates protein search for targets on DNAen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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