Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome

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dc.citation.articleNumber2211241en_US
dc.citation.issueNumber10en_US
dc.citation.journalTitleAdvanced Materialsen_US
dc.citation.volumeNumber36en_US
dc.contributor.authorDerry, Paul J.en_US
dc.contributor.authorLiopo, Anton V.en_US
dc.contributor.authorMouli, Karthiken_US
dc.contributor.authorMcHugh, Emily A.en_US
dc.contributor.authorVo, Anh T. T.en_US
dc.contributor.authorMcKelvey, Annen_US
dc.contributor.authorSuva, Larry J.en_US
dc.contributor.authorWu, Gangen_US
dc.contributor.authorGao, Yanen_US
dc.contributor.authorOlson, Kenneth R.en_US
dc.contributor.authorTour, James M.en_US
dc.contributor.authorKent, Thomas A.en_US
dc.contributor.orgSmalley-Curl Instituteen_US
dc.contributor.orgWelch Institute for Advanced Materialsen_US
dc.contributor.orgThe NanoCarbon Centeren_US
dc.date.accessioned2024-07-25T20:56:27Zen_US
dc.date.available2024-07-25T20:56:27Zen_US
dc.date.issued2024en_US
dc.description.abstractHydrogen sulfide (H2S) is a noxious, potentially poisonous, but necessary gas produced from sulfur metabolism in humans. In Down Syndrome (DS), the production of H2S is elevated and associated with degraded mitochondrial function. Therefore, removing H2S from the body as a stable oxide could be an approach to reducing the deleterious effects of H2S in DS. In this report we describe the catalytic oxidation of hydrogen sulfide (H2S) to polysulfides (HS2+nāˆ’) and thiosulfate (S2O32āˆ’) by poly(ethylene glycol) hydrophilic carbon clusters (PEG-HCCs) and poly(ethylene glycol) oxidized activated charcoal (PEG-OACs), examples of oxidized carbon nanozymes (OCNs). We show that OCNs oxidize H2S to polysulfides and S2O32āˆ’ in a dose-dependent manner. The reaction is dependent on O2 and the presence of quinone groups on the OCNs. In DS donor lymphocytes we found that OCNs increased polysulfide production, proliferation, and afforded protection against additional toxic levels of H2S compared to untreated DS lymphocytes. Finally, in Dp16 and Ts65DN murine models of DS, we found that OCNs restored osteoclast differentiation. This new action suggests potential facile translation into the clinic for conditions involving excess H2S exemplified by DS.en_US
dc.identifier.citationDerry, P. J., Liopo, A. V., Mouli, K., McHugh, E. A., Vo, A. T. T., McKelvey, A., Suva, L. J., Wu, G., Gao, Y., Olson, K. R., Tour, J. M., & Kent, T. A. (2024). Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome. Advanced Materials, 36(10), 2211241. https://doi.org/10.1002/adma.202211241en_US
dc.identifier.digitalOxidation-Hydrogen-Sulfideen_US
dc.identifier.doihttps://doi.org/10.1002/adma.202211241en_US
dc.identifier.urihttps://hdl.handle.net/1911/117536en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleOxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndromeen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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