Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome
dc.citation.articleNumber | 2211241 | |
dc.citation.issueNumber | 10 | |
dc.citation.journalTitle | Advanced Materials | |
dc.citation.volumeNumber | 36 | |
dc.contributor.author | Derry, Paul J. | |
dc.contributor.author | Liopo, Anton V. | |
dc.contributor.author | Mouli, Karthik | |
dc.contributor.author | McHugh, Emily A. | |
dc.contributor.author | Vo, Anh T. T. | |
dc.contributor.author | McKelvey, Ann | |
dc.contributor.author | Suva, Larry J. | |
dc.contributor.author | Wu, Gang | |
dc.contributor.author | Gao, Yan | |
dc.contributor.author | Olson, Kenneth R. | |
dc.contributor.author | Tour, James M. | |
dc.contributor.author | Kent, Thomas A. | |
dc.contributor.org | Smalley-Curl Institute | |
dc.contributor.org | Welch Institute for Advanced Materials | |
dc.contributor.org | The NanoCarbon Center | |
dc.date.accessioned | 2024-07-25T20:56:27Z | |
dc.date.available | 2024-07-25T20:56:27Z | |
dc.date.issued | 2024 | |
dc.description.abstract | Hydrogen sulfide (H2S) is a noxious, potentially poisonous, but necessary gas produced from sulfur metabolism in humans. In Down Syndrome (DS), the production of H2S is elevated and associated with degraded mitochondrial function. Therefore, removing H2S from the body as a stable oxide could be an approach to reducing the deleterious effects of H2S in DS. In this report we describe the catalytic oxidation of hydrogen sulfide (H2S) to polysulfides (HS2+nā) and thiosulfate (S2O32ā) by poly(ethylene glycol) hydrophilic carbon clusters (PEG-HCCs) and poly(ethylene glycol) oxidized activated charcoal (PEG-OACs), examples of oxidized carbon nanozymes (OCNs). We show that OCNs oxidize H2S to polysulfides and S2O32ā in a dose-dependent manner. The reaction is dependent on O2 and the presence of quinone groups on the OCNs. In DS donor lymphocytes we found that OCNs increased polysulfide production, proliferation, and afforded protection against additional toxic levels of H2S compared to untreated DS lymphocytes. Finally, in Dp16 and Ts65DN murine models of DS, we found that OCNs restored osteoclast differentiation. This new action suggests potential facile translation into the clinic for conditions involving excess H2S exemplified by DS. | |
dc.identifier.citation | Derry, P. J., Liopo, A. V., Mouli, K., McHugh, E. A., Vo, A. T. T., McKelvey, A., Suva, L. J., Wu, G., Gao, Y., Olson, K. R., Tour, J. M., & Kent, T. A. (2024). Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome. Advanced Materials, 36(10), 2211241. https://doi.org/10.1002/adma.202211241 | |
dc.identifier.digital | Oxidation-Hydrogen-Sulfide | |
dc.identifier.doi | https://doi.org/10.1002/adma.202211241 | |
dc.identifier.uri | https://hdl.handle.net/1911/117536 | |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.rights | Except where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder. | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.title | Oxidation of Hydrogen Sulfide to Polysulfide and Thiosulfate by a Carbon Nanozyme: Therapeutic Implications with an Emphasis on Down Syndrome | |
dc.type | Journal article | |
dc.type.dcmi | Text | |
dc.type.publication | publisher version |
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