Geometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of cancer

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dc.citation.firstpage97en_US
dc.citation.issueNumber1en_US
dc.citation.journalTitleCancer Lettersen_US
dc.citation.lastpage101en_US
dc.citation.volumeNumber352en_US
dc.contributor.authorGizzatov, Ayraten_US
dc.contributor.authorStigliano, Cinziaen_US
dc.contributor.authorAnanta, Jeyerama S.en_US
dc.contributor.authorSethi, Richaen_US
dc.contributor.authorXu, Rongen_US
dc.contributor.authorGuven, Ademen_US
dc.contributor.authorRamirez, Maricelaen_US
dc.contributor.authorShen, Haifaen_US
dc.contributor.authorSood, Anilen_US
dc.contributor.authorFerrari, Mauroen_US
dc.contributor.authorWilson, Lon J.en_US
dc.contributor.authorLiu, Xuewuen_US
dc.contributor.authorDecuzzi, Paoloen_US
dc.contributor.orgSmalley Institute for Nanoscale Science and Technologyen_US
dc.date.accessioned2015-10-28T19:04:03Zen_US
dc.date.available2015-10-28T19:04:03Zen_US
dc.date.issued2014en_US
dc.description.abstractPorous silicon has been used for the delivery of therapeutic and imaging agents in several biomedical applications. Here, mesoporous silicon nanoconstructs (SiMPs) with a discoidal shape and a sub-micrometer size (1,000 × 400 nm) have been conjugated with gadolinium-tetraazacyclododecane tetraacetic acid Gd(DOTA) molecules and proposed as contrast agents for Magnetic Resonance Imaging. The surface of the SiMPs with different porosities – small pore (SP: ~ 5 nm) and huge pore (HP: ~ 40 nm) – and of bulk, non-porous silica beads (1,000 nm in diameter) have been modified with covalently attached (3-aminopropyl)triethoxysilane (APTES) groups, conjugated with DOTA molecules, and reacted with an aqueous solution of GdCl3. The resulting Gd(DOTA) molecules confined within the small pores of the Gd-SiMPs achieve longitudinal relaxivities r1 of ~ 17 (mM·s)−1, which is 4 times greater than for free Gd(DOTA). This enhancement is ascribed to the confinement and stable chelation of Gd(DOTA) molecules within the SiMP mesoporous matrix. The resulting nanoconstructs possess no cytotoxicity and accumulate in ovarian tumors up to 2% of the injected dose per gram tissue, upon tail vein injection. All together this data suggests that Gd-SiMPs could be efficiently used for MR vascular imaging in cancer and other diseases.en_US
dc.identifier.citationGizzatov, Ayrat, Stigliano, Cinzia, Ananta, Jeyerama S., et al.. "Geometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of cancer." <i>Cancer Letters,</i> 352, no. 1 (2014) Elsevier: 97-101. http://dx.doi.org/10.1016/j.canlet.2014.06.001.en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.canlet.2014.06.001en_US
dc.identifier.urihttps://hdl.handle.net/1911/81937en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordnanoconstructsen_US
dc.subject.keywordMagnetic Resonance Imagingen_US
dc.subject.keywordmesoporous siliconen_US
dc.subject.keywordrelaxivityen_US
dc.titleGeometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of canceren_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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