Geometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of cancer

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dc.citation.firstpage97
dc.citation.issueNumber1
dc.citation.journalTitleCancer Letters
dc.citation.lastpage101
dc.citation.volumeNumber352
dc.contributor.authorGizzatov, Ayrat
dc.contributor.authorStigliano, Cinzia
dc.contributor.authorAnanta, Jeyerama S.
dc.contributor.authorSethi, Richa
dc.contributor.authorXu, Rong
dc.contributor.authorGuven, Adem
dc.contributor.authorRamirez, Maricela
dc.contributor.authorShen, Haifa
dc.contributor.authorSood, Anil
dc.contributor.authorFerrari, Mauro
dc.contributor.authorWilson, Lon J.
dc.contributor.authorLiu, Xuewu
dc.contributor.authorDecuzzi, Paolo
dc.contributor.orgSmalley Institute for Nanoscale Science and Technology
dc.date.accessioned2015-10-28T19:04:03Z
dc.date.available2015-10-28T19:04:03Z
dc.date.issued2014
dc.description.abstractPorous silicon has been used for the delivery of therapeutic and imaging agents in several biomedical applications. Here, mesoporous silicon nanoconstructs (SiMPs) with a discoidal shape and a sub-micrometer size (1,000 × 400 nm) have been conjugated with gadolinium-tetraazacyclododecane tetraacetic acid Gd(DOTA) molecules and proposed as contrast agents for Magnetic Resonance Imaging. The surface of the SiMPs with different porosities – small pore (SP: ~ 5 nm) and huge pore (HP: ~ 40 nm) – and of bulk, non-porous silica beads (1,000 nm in diameter) have been modified with covalently attached (3-aminopropyl)triethoxysilane (APTES) groups, conjugated with DOTA molecules, and reacted with an aqueous solution of GdCl3. The resulting Gd(DOTA) molecules confined within the small pores of the Gd-SiMPs achieve longitudinal relaxivities r1 of ~ 17 (mM·s)−1, which is 4 times greater than for free Gd(DOTA). This enhancement is ascribed to the confinement and stable chelation of Gd(DOTA) molecules within the SiMP mesoporous matrix. The resulting nanoconstructs possess no cytotoxicity and accumulate in ovarian tumors up to 2% of the injected dose per gram tissue, upon tail vein injection. All together this data suggests that Gd-SiMPs could be efficiently used for MR vascular imaging in cancer and other diseases.
dc.identifier.citationGizzatov, Ayrat, Stigliano, Cinzia, Ananta, Jeyerama S., et al.. "Geometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of cancer." <i>Cancer Letters,</i> 352, no. 1 (2014) Elsevier: 97-101. http://dx.doi.org/10.1016/j.canlet.2014.06.001.
dc.identifier.doihttp://dx.doi.org/10.1016/j.canlet.2014.06.001
dc.identifier.urihttps://hdl.handle.net/1911/81937
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.subject.keywordnanoconstructs
dc.subject.keywordMagnetic Resonance Imaging
dc.subject.keywordmesoporous silicon
dc.subject.keywordrelaxivity
dc.titleGeometrical confinement of Gd(DOTA) molecules within mesoporous silicon nanoconstructs for MR imaging of cancer
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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