Periodic, Quasi-periodic and Chaotic Dynamics in Simple Gene Elements with Time Delays

Simple item page
dc.citation.journalTitleScientific Reportsen_US
dc.citation.volumeNumber6en_US
dc.contributor.authorSuzuki, Yokoen_US
dc.contributor.authorLu, Mingyangen_US
dc.contributor.authorBen-Jacob, Eshelen_US
dc.contributor.authorOnuchic, José Nelsonen_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2016-04-04T20:15:21Zen_US
dc.date.available2016-04-04T20:15:21Zen_US
dc.date.issued2016en_US
dc.description.abstractRegulatory gene circuit motifs play crucial roles in performing and maintaining vital cellular functions. Frequently, theoretical studies of gene circuits focus on steady-state behaviors and do not include time delays. In this study, the inclusion of time delays is shown to entirely change the time-dependent dynamics for even the simplest possible circuits with one and two gene elements with self and cross regulations. These elements can give rise to rich behaviors including periodic, quasi-periodic, weak chaotic, strong chaotic and intermittent dynamics. We introduce a special power-spectrum-based method to characterize and discriminate these dynamical modes quantitatively. Our simulation results suggest that, while a single negative feedback loop of either one- or two-gene element can only have periodic dynamics, the elements with two positive/negative feedback loops are the minimalist elements to have chaotic dynamics. These elements typically have one negative feedback loop that generates oscillations, and another unit that allows frequent switches among multiple steady states or between oscillatory and non-oscillatory dynamics. Possible dynamical features of several simple one- and two-gene elements are presented in details. Discussion is presented for possible roles of the chaotic behavior in the robustness of cellular functions and diseases, for example, in the context of cancer.en_US
dc.identifier.citationSuzuki, Yoko, Lu, Mingyang, Ben-Jacob, Eshel, et al.. "Periodic, Quasi-periodic and Chaotic Dynamics in Simple Gene Elements with Time Delays." <i>Scientific Reports,</i> 6, (2016) Macmillan Publishers Limited: http://dx.doi.org/10.1038/srep21037.en_US
dc.identifier.doihttp://dx.doi.org/10.1038/srep21037en_US
dc.identifier.urihttps://hdl.handle.net/1911/88838en_US
dc.language.isoengen_US
dc.publisherMacmillan Publishers Limiteden_US
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titlePeriodic, Quasi-periodic and Chaotic Dynamics in Simple Gene Elements with Time Delaysen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
srep21037.pdf
Size:
2.35 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications
Biochemistry and Cell Biology Publications
Chemistry Publications