Improved understanding of biorisk for research involving microbial modification using annotated sequences of concern

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dc.citation.articleNumber1124100en_US
dc.citation.journalTitleFrontiers in Bioengineering and Biotechnologyen_US
dc.citation.volumeNumber11en_US
dc.contributor.authorGodbold, Gene D.en_US
dc.contributor.authorHewitt, F. Curtisen_US
dc.contributor.authorKappell, Anthony D.en_US
dc.contributor.authorScholz, Matthew B.en_US
dc.contributor.authorAgar, Stacy L.en_US
dc.contributor.authorTreangen, Todd J.en_US
dc.contributor.authorTernus, Krista L.en_US
dc.contributor.authorSandbrink, Jonas B.en_US
dc.contributor.authorKoblentz, Gregory D.en_US
dc.date.accessioned2023-07-21T16:13:47Zen_US
dc.date.available2023-07-21T16:13:47Zen_US
dc.date.issued2023en_US
dc.description.abstractRegulation of research on microbes that cause disease in humans has historically been focused on taxonomic lists of ‘bad bugs’. However, given our increased knowledge of these pathogens through inexpensive genome sequencing, 5 decades of research in microbial pathogenesis, and the burgeoning capacity of synthetic biologists, the limitations of this approach are apparent. With heightened scientific and public attention focused on biosafety and biosecurity, and an ongoing review by US authorities of dual-use research oversight, this article proposes the incorporation of sequences of concern (SoCs) into the biorisk management regime governing genetic engineering of pathogens. SoCs enable pathogenesis in all microbes infecting hosts that are ‘of concern’ to human civilization. Here we review the functions of SoCs (FunSoCs) and discuss how they might bring clarity to potentially problematic research outcomes involving infectious agents. We believe that annotation of SoCs with FunSoCs has the potential to improve the likelihood that dual use research of concern is recognized by both scientists and regulators before it occurs.en_US
dc.identifier.citationGodbold, Gene D., Hewitt, F. Curtis, Kappell, Anthony D., et al.. "Improved understanding of biorisk for research involving microbial modification using annotated sequences of concern." <i>Frontiers in Bioengineering and Biotechnology,</i> 11, (2023) Frontiers Media S.A.: https://doi.org/10.3389/fbioe.2023.1124100.en_US
dc.identifier.digitalfbioe-11-1124100en_US
dc.identifier.doihttps://doi.org/10.3389/fbioe.2023.1124100en_US
dc.identifier.urihttps://hdl.handle.net/1911/114986en_US
dc.language.isoengen_US
dc.publisherFrontiers Media S.A.en_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of Fair Use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleImproved understanding of biorisk for research involving microbial modification using annotated sequences of concernen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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