Protein target highlights in CASP15: Analysis of models by structure providers

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dc.citation.firstpage1571en_US
dc.citation.issueNumber12en_US
dc.citation.journalTitleProteins: Structure, Function, and Bioinformaticsen_US
dc.citation.lastpage1599en_US
dc.citation.volumeNumber91en_US
dc.contributor.authorAlexander, Leila T.en_US
dc.contributor.authorDurairaj, Jananien_US
dc.contributor.authorKryshtafovych, Andriyen_US
dc.contributor.authorAbriata, Luciano A.en_US
dc.contributor.authorBayo, Yusuphaen_US
dc.contributor.authorBhabha, Giraen_US
dc.contributor.authorBreyton, Cécileen_US
dc.contributor.authorCaulton, Simon G.en_US
dc.contributor.authorChen, Jamesen_US
dc.contributor.authorDegroux, Séraphineen_US
dc.contributor.authorEkiert, Damian C.en_US
dc.contributor.authorErlandsen, Benedikte S.en_US
dc.contributor.authorFreddolino, Peter L.en_US
dc.contributor.authorGilzer, Dominicen_US
dc.contributor.authorGreening, Chrisen_US
dc.contributor.authorGrimes, Jonathan M.en_US
dc.contributor.authorGrinter, Rhysen_US
dc.contributor.authorGurusaran, Manickamen_US
dc.contributor.authorHartmann, Marcus D.en_US
dc.contributor.authorHitchman, Charlie J.en_US
dc.contributor.authorKeown, Jeremy R.en_US
dc.contributor.authorKropp, Ashleighen_US
dc.contributor.authorKursula, Petrien_US
dc.contributor.authorLovering, Andrew L.en_US
dc.contributor.authorLemaitre, Brunoen_US
dc.contributor.authorLia, Andreaen_US
dc.contributor.authorLiu, Shihengen_US
dc.contributor.authorLogotheti, Mariaen_US
dc.contributor.authorLu, Shuzeen_US
dc.contributor.authorMarkússon, Sigurbjörnen_US
dc.contributor.authorMiller, Mitchell D.en_US
dc.contributor.authorMinasov, Georgeen_US
dc.contributor.authorNiemann, Hartmut H.en_US
dc.contributor.authorOpazo, Felipeen_US
dc.contributor.authorPhillips Jr, George N.en_US
dc.contributor.authorDavies, Owen R.en_US
dc.contributor.authorRommelaere, Samuelen_US
dc.contributor.authorRosas-Lemus, Monicaen_US
dc.contributor.authorRoversi, Pietroen_US
dc.contributor.authorSatchell, Karlaen_US
dc.contributor.authorSmith, Nathanen_US
dc.contributor.authorWilson, Mark A.en_US
dc.contributor.authorWu, Kuan-Linen_US
dc.contributor.authorXia, Xianen_US
dc.contributor.authorXiao, Hanen_US
dc.contributor.authorZhang, Wenhuaen_US
dc.contributor.authorZhou, Z. Hongen_US
dc.contributor.authorFidelis, Krzysztofen_US
dc.contributor.authorTopf, Mayaen_US
dc.contributor.authorMoult, Johnen_US
dc.contributor.authorSchwede, Torstenen_US
dc.date.accessioned2024-05-03T15:51:08Zen_US
dc.date.available2024-05-03T15:51:08Zen_US
dc.date.issued2023en_US
dc.description.abstractWe present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.en_US
dc.identifier.citationAlexander, L. T., Durairaj, J., Kryshtafovych, A., Abriata, L. A., Bayo, Y., Bhabha, G., Breyton, C., Caulton, S. G., Chen, J., Degroux, S., Ekiert, D. C., Erlandsen, B. S., Freddolino, P. L., Gilzer, D., Greening, C., Grimes, J. M., Grinter, R., Gurusaran, M., Hartmann, M. D., … Schwede, T. (2023). Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics, 91(12), 1571–1599. https://doi.org/10.1002/prot.26545en_US
dc.identifier.digitalProtein-target-highlightsen_US
dc.identifier.doihttps://doi.org/10.1002/prot.26545en_US
dc.identifier.urihttps://hdl.handle.net/1911/115537en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleProtein target highlights in CASP15: Analysis of models by structure providersen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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