Protein target highlights in CASP15: Analysis of models by structure providers

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dc.citation.firstpage1571
dc.citation.issueNumber12
dc.citation.journalTitleProteins: Structure, Function, and Bioinformatics
dc.citation.lastpage1599
dc.citation.volumeNumber91
dc.contributor.authorAlexander, Leila T.
dc.contributor.authorDurairaj, Janani
dc.contributor.authorKryshtafovych, Andriy
dc.contributor.authorAbriata, Luciano A.
dc.contributor.authorBayo, Yusupha
dc.contributor.authorBhabha, Gira
dc.contributor.authorBreyton, Cécile
dc.contributor.authorCaulton, Simon G.
dc.contributor.authorChen, James
dc.contributor.authorDegroux, Séraphine
dc.contributor.authorEkiert, Damian C.
dc.contributor.authorErlandsen, Benedikte S.
dc.contributor.authorFreddolino, Peter L.
dc.contributor.authorGilzer, Dominic
dc.contributor.authorGreening, Chris
dc.contributor.authorGrimes, Jonathan M.
dc.contributor.authorGrinter, Rhys
dc.contributor.authorGurusaran, Manickam
dc.contributor.authorHartmann, Marcus D.
dc.contributor.authorHitchman, Charlie J.
dc.contributor.authorKeown, Jeremy R.
dc.contributor.authorKropp, Ashleigh
dc.contributor.authorKursula, Petri
dc.contributor.authorLovering, Andrew L.
dc.contributor.authorLemaitre, Bruno
dc.contributor.authorLia, Andrea
dc.contributor.authorLiu, Shiheng
dc.contributor.authorLogotheti, Maria
dc.contributor.authorLu, Shuze
dc.contributor.authorMarkússon, Sigurbjörn
dc.contributor.authorMiller, Mitchell D.
dc.contributor.authorMinasov, George
dc.contributor.authorNiemann, Hartmut H.
dc.contributor.authorOpazo, Felipe
dc.contributor.authorPhillips Jr, George N.
dc.contributor.authorDavies, Owen R.
dc.contributor.authorRommelaere, Samuel
dc.contributor.authorRosas-Lemus, Monica
dc.contributor.authorRoversi, Pietro
dc.contributor.authorSatchell, Karla
dc.contributor.authorSmith, Nathan
dc.contributor.authorWilson, Mark A.
dc.contributor.authorWu, Kuan-Lin
dc.contributor.authorXia, Xian
dc.contributor.authorXiao, Han
dc.contributor.authorZhang, Wenhua
dc.contributor.authorZhou, Z. Hong
dc.contributor.authorFidelis, Krzysztof
dc.contributor.authorTopf, Maya
dc.contributor.authorMoult, John
dc.contributor.authorSchwede, Torsten
dc.date.accessioned2024-05-03T15:51:08Z
dc.date.available2024-05-03T15:51:08Z
dc.date.issued2023
dc.description.abstractWe present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.
dc.identifier.citationAlexander, L. T., Durairaj, J., Kryshtafovych, A., Abriata, L. A., Bayo, Y., Bhabha, G., Breyton, C., Caulton, S. G., Chen, J., Degroux, S., Ekiert, D. C., Erlandsen, B. S., Freddolino, P. L., Gilzer, D., Greening, C., Grimes, J. M., Grinter, R., Gurusaran, M., Hartmann, M. D., … Schwede, T. (2023). Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics, 91(12), 1571–1599. https://doi.org/10.1002/prot.26545
dc.identifier.digitalProtein-target-highlights
dc.identifier.doihttps://doi.org/10.1002/prot.26545
dc.identifier.urihttps://hdl.handle.net/1911/115537
dc.language.isoeng
dc.publisherWiley
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleProtein target highlights in CASP15: Analysis of models by structure providers
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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