Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism

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dc.citation.articleNumber77
dc.citation.journalTitleGenome Biology
dc.citation.volumeNumber25
dc.contributor.authorPujadas Liwag, Emily M.
dc.contributor.authorWei, Xiaolong
dc.contributor.authorAcosta, Nicolas
dc.contributor.authorCarter, Lucas M.
dc.contributor.authorYang, Jiekun
dc.contributor.authorAlmassalha, Luay M.
dc.contributor.authorJain, Surbhi
dc.contributor.authorDaneshkhah, Ali
dc.contributor.authorRao, Suhas S. P.
dc.contributor.authorSeker-Polat, Fidan
dc.contributor.authorMacQuarrie, Kyle L.
dc.contributor.authorIbarra, Joe
dc.contributor.authorAgrawal, Vasundhara
dc.contributor.authorAiden, Erez Lieberman
dc.contributor.authorKanemaki, Masato T.
dc.contributor.authorBackman, Vadim
dc.contributor.authorAdli, Mazhar
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2024-08-02T13:32:10Z
dc.date.available2024-08-02T13:32:10Z
dc.date.issued2024
dc.description.abstractB-type lamins are critical nuclear envelope proteins that interact with the three-dimensional genomic architecture. However, identifying the direct roles of B-lamins on dynamic genome organization has been challenging as their joint depletion severely impacts cell viability. To overcome this, we engineered mammalian cells to rapidly and completely degrade endogenous B-type lamins using Auxin-inducible degron technology.
dc.identifier.citationPujadas Liwag, E. M., Wei, X., Acosta, N., Carter, L. M., Yang, J., Almassalha, L. M., Jain, S., Daneshkhah, A., Rao, S. S. P., Seker-Polat, F., MacQuarrie, K. L., Ibarra, J., Agrawal, V., Aiden, E. L., Kanemaki, M. T., Backman, V., & Adli, M. (2024). Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism. Genome Biology, 25(1), 77. https://doi.org/10.1186/s13059-024-03212-y
dc.identifier.digitals13059-024-03212-y
dc.identifier.doihttps://doi.org/10.1186/s13059-024-03212-y
dc.identifier.urihttps://hdl.handle.net/1911/117582
dc.language.isoeng
dc.publisherSpringer Nature
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleDepletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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