Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism

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dc.citation.articleNumber77en_US
dc.citation.journalTitleGenome Biologyen_US
dc.citation.volumeNumber25en_US
dc.contributor.authorPujadas Liwag, Emily M.en_US
dc.contributor.authorWei, Xiaolongen_US
dc.contributor.authorAcosta, Nicolasen_US
dc.contributor.authorCarter, Lucas M.en_US
dc.contributor.authorYang, Jiekunen_US
dc.contributor.authorAlmassalha, Luay M.en_US
dc.contributor.authorJain, Surbhien_US
dc.contributor.authorDaneshkhah, Alien_US
dc.contributor.authorRao, Suhas S. P.en_US
dc.contributor.authorSeker-Polat, Fidanen_US
dc.contributor.authorMacQuarrie, Kyle L.en_US
dc.contributor.authorIbarra, Joeen_US
dc.contributor.authorAgrawal, Vasundharaen_US
dc.contributor.authorAiden, Erez Liebermanen_US
dc.contributor.authorKanemaki, Masato T.en_US
dc.contributor.authorBackman, Vadimen_US
dc.contributor.authorAdli, Mazharen_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2024-08-02T13:32:10Zen_US
dc.date.available2024-08-02T13:32:10Zen_US
dc.date.issued2024en_US
dc.description.abstractB-type lamins are critical nuclear envelope proteins that interact with the three-dimensional genomic architecture. However, identifying the direct roles of B-lamins on dynamic genome organization has been challenging as their joint depletion severely impacts cell viability. To overcome this, we engineered mammalian cells to rapidly and completely degrade endogenous B-type lamins using Auxin-inducible degron technology.en_US
dc.identifier.citationPujadas Liwag, E. M., Wei, X., Acosta, N., Carter, L. M., Yang, J., Almassalha, L. M., Jain, S., Daneshkhah, A., Rao, S. S. P., Seker-Polat, F., MacQuarrie, K. L., Ibarra, J., Agrawal, V., Aiden, E. L., Kanemaki, M. T., Backman, V., & Adli, M. (2024). Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism. Genome Biology, 25(1), 77. https://doi.org/10.1186/s13059-024-03212-yen_US
dc.identifier.digitals13059-024-03212-yen_US
dc.identifier.doihttps://doi.org/10.1186/s13059-024-03212-yen_US
dc.identifier.urihttps://hdl.handle.net/1911/117582en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleDepletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanismen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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