Accuracy of In Vivo Multimodal Optical Imaging for Detection of Oral Neoplasia

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dc.citation.firstpage801en_US
dc.citation.journalTitleCancer Prevention Researchen_US
dc.citation.lastpage809en_US
dc.citation.volumeNumber5en_US
dc.contributor.authorPierce, Mark C.en_US
dc.contributor.authorSchwarz, Richard A.en_US
dc.contributor.authorBhattar, Vijayashree S.en_US
dc.contributor.authorMondrik, Sharonen_US
dc.contributor.authorWilliams, Michelle D.en_US
dc.contributor.authorLee, J. Jacken_US
dc.contributor.authorRichards-Kortum, Rebeccaen_US
dc.contributor.authorGillenwater, Ann M.en_US
dc.date.accessioned2013-08-20T22:10:08Zen_US
dc.date.available2013-08-20T22:10:08Zen_US
dc.date.issued2012en_US
dc.description.abstractIf detected early, oral cancer is eminently curable. However, survival rates for oral cancer patients remain low, largely due to late-stage diagnosis and subsequent difficulty of treatment. To improve cliniciansﾒ ability to detect early disease and to treat advanced cancers, we developed a multimodal optical imaging system (MMIS) to evaluate tissue in situ, at macroscopic and microscopic scales. The MMIS was used to measure 100 anatomic sites in 30 patients, correctly classifying 98% of pathologically confirmed normal tissue sites, and 95% of sites graded as moderate dysplasia, severe dysplasia, or cancer. When used alone, MMIS classification accuracy was 35% for sites determined by pathology as mild dysplasia. However, MMIS measurements correlated with expression of candidate molecular markers in 87% of sites with mild dysplasia. These findings support the ability of noninvasive multimodal optical imaging to accurately identify neoplastic tissue and premalignant lesions. This in turn may have considerable impact on detection and treatment of patients with oral cancer and other epithelial malignancies.en_US
dc.embargo.termsnoneen_US
dc.identifier.citationPierce, Mark C., Schwarz, Richard A., Bhattar, Vijayashree S., et al.. "Accuracy of In Vivo Multimodal Optical Imaging for Detection of Oral Neoplasia." <i>Cancer Prevention Research,</i> 5, (2012) AACR: 801-809. http://dx.doi.org/10.1158/1940-6207.CAPR-11-0555.en_US
dc.identifier.doihttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0555en_US
dc.identifier.urihttps://hdl.handle.net/1911/71746en_US
dc.language.isoengen_US
dc.publisherAACRen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.titleAccuracy of In Vivo Multimodal Optical Imaging for Detection of Oral Neoplasiaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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