Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents

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dc.citation.firstpage8378en_US
dc.citation.journalTitleNanoscaleen_US
dc.citation.lastpage8388en_US
dc.citation.volumeNumber7en_US
dc.contributor.authorPoulose, Aby Cheruvathooren_US
dc.contributor.authorVeeranarayanan, Srivanien_US
dc.contributor.authorMohamed, M. Sheikhen_US
dc.contributor.authorNagaoka, Yutakaen_US
dc.contributor.authorAburto, Rebeca Romeroen_US
dc.contributor.authorMitcham, Trevoren_US
dc.contributor.authorAjayan, Pulickel M.en_US
dc.contributor.authorBouchard, Richard R.en_US
dc.contributor.authorSakamoto, Yasushien_US
dc.contributor.authorYoshida, Yasuhikoen_US
dc.contributor.authorMaekawa, Toruen_US
dc.contributor.authorKumar, D. Sakthien_US
dc.date.accessioned2016-08-30T20:50:15Zen_US
dc.date.available2016-08-30T20:50:15Zen_US
dc.date.issued2015en_US
dc.description.abstractA size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo- and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration. The simple synthesis protocol, combined with the multitudes of interesting features packed into a single nanoformulation, clearly demonstrates the competing role of this Cu2S nanosystem in future cancer treatment strategies.en_US
dc.identifier.citationPoulose, Aby Cheruvathoor, Veeranarayanan, Srivani, Mohamed, M. Sheikh, et al.. "Multi-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agents." <i>Nanoscale,</i> 7, (2015) Royal Society of Chemistry: 8378-8388. http://dx.doi.org/10.1039/C4NR07139E.en_US
dc.identifier.doihttp://dx.doi.org/10.1039/C4NR07139Een_US
dc.identifier.urihttps://hdl.handle.net/1911/91373en_US
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the Royal Society of Chemistry.en_US
dc.titleMulti-stimuli responsive Cu2S nanocrystals as trimodal imaging and synergistic chemo-photothermal therapy agentsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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