Slowdown of growth controls cellular differentiation

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dc.citation.articleNumber871en_US
dc.citation.journalTitleMolecular Systems Biologyen_US
dc.citation.volumeNumber12en_US
dc.contributor.authorNarula, Jatinen_US
dc.contributor.authorKuchina, Annaen_US
dc.contributor.authorZhang, Fangen_US
dc.contributor.authorFujita, Masayaen_US
dc.contributor.authorSüel, Gürol M.en_US
dc.contributor.authorIgoshin, Oleg A.en_US
dc.date.accessioned2016-07-06T19:28:53Zen_US
dc.date.available2016-07-06T19:28:53Zen_US
dc.date.issued2016en_US
dc.description.abstractHow can changes in growth rate affect the regulatory networks behavior and the outcomes of cellular differentiation? We address this question by focusing on starvation response in sporulating Bacillus subtilis. We show that the activity of sporulation master regulator Spo0A increases with decreasing cellular growth rate. Using a mathematical model of the phosphorelay—the network controlling Spo0A—we predict that this increase in Spo0A activity can be explained by the phosphorelay protein accumulation and lengthening of the period between chromosomal replication events caused by growth slowdown. As a result, only cells growing slower than a certain rate reach threshold Spo0A activity necessary for sporulation. This growth threshold model accurately predicts cell fates and explains the distribution of sporulation deferral times. We confirm our predictions experimentally and show that the concentration rather than activity of phosphorelay proteins is affected by the growth slowdown. We conclude that sensing the growth rates enables cells to indirectly detect starvation without the need for evaluating specific stress signals.en_US
dc.identifier.citationNarula, Jatin, Kuchina, Anna, Zhang, Fang, et al.. "Slowdown of growth controls cellular differentiation." <i>Molecular Systems Biology,</i> 12, (2016) EMBO Press: http://dx.doi.org/10.15252/msb.20156691.en_US
dc.identifier.doihttp://dx.doi.org/10.15252/msb.20156691en_US
dc.identifier.urihttps://hdl.handle.net/1911/90814en_US
dc.language.isoengen_US
dc.publisherEMBO Pressen_US
dc.rightsThis is an open access article under the terms of the Creative Commons Attribution 4.0 License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleSlowdown of growth controls cellular differentiationen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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