Multiple neuronal networks coordinate Hydra mechanosensory behavior
| dc.citation.articleNumber | e64108 | en_US |
| dc.citation.journalTitle | eLife | en_US |
| dc.citation.volumeNumber | 10 | en_US |
| dc.contributor.author | Badhiwala, Krishna N. | en_US |
| dc.contributor.author | Primack, Abby S. | en_US |
| dc.contributor.author | Juliano, Celina E. | en_US |
| dc.contributor.author | Robinson, Jacob T. | en_US |
| dc.contributor.org | Bioengineering | en_US |
| dc.contributor.org | Electrical and Computer Engineering | en_US |
| dc.date.accessioned | 2021-08-20T20:24:33Z | en_US |
| dc.date.available | 2021-08-20T20:24:33Z | en_US |
| dc.date.issued | 2021 | en_US |
| dc.description.abstract | Hydra vulgaris is an emerging model organism for neuroscience due to its small size, transparency, genetic tractability, and regenerative nervous system; however, fundamental properties of its sensorimotor behaviors remain unknown. Here, we use microfluidic devices combined with fluorescent calcium imaging and surgical resectioning to study how the diffuse nervous system coordinates Hydra's mechanosensory response. Mechanical stimuli cause animals to contract, and we find this response relies on at least two distinct networks of neurons in the oral and aboral regions of the animal. Different activity patterns arise in these networks depending on whether the animal is contracting spontaneously or contracting in response to mechanical stimulation. Together, these findings improve our understanding of how Hydra’s diffuse nervous system coordinates sensorimotor behaviors. These insights help reveal how sensory information is processed in an animal with a diffuse, radially symmetric neural architecture unlike the dense, bilaterally symmetric nervous systems found in most model organisms. | en_US |
| dc.identifier.citation | Badhiwala, Krishna N., Primack, Abby S., Juliano, Celina E., et al.. "Multiple neuronal networks coordinate Hydra mechanosensory behavior." <i>eLife,</i> 10, (2021) eLife Sciences Publications Ltd.: https://doi.org/10.7554/eLife.64108. | en_US |
| dc.identifier.digital | elife-64108-v2 | en_US |
| dc.identifier.doi | https://doi.org/10.7554/eLife.64108 | en_US |
| dc.identifier.uri | https://hdl.handle.net/1911/111314 | en_US |
| dc.language.iso | eng | en_US |
| dc.publisher | eLife Sciences Publications Ltd. | en_US |
| dc.rights | This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. | en_US |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
| dc.title | Multiple neuronal networks coordinate Hydra mechanosensory behavior | en_US |
| dc.type | Journal article | en_US |
| dc.type.dcmi | Text | en_US |
| dc.type.publication | publisher version | en_US |
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