Citrate-Capped Gold Nanoparticle Electrophoretic Heat Production in Response to a Time-Varying Radio-Frequency Electric Field

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dc.citation.firstpage24380en_US
dc.citation.issueNumber45en_US
dc.citation.journalTitleThe Journal of Physical Chemistry Cen_US
dc.citation.lastpage24389en_US
dc.citation.volumeNumber116en_US
dc.contributor.authorCorr, Stuart J.en_US
dc.contributor.authorRaoof, Mustafaen_US
dc.contributor.authorMackeyev, Yurien_US
dc.contributor.authorPhounsavath, Sophiaen_US
dc.contributor.authorCheney, Matthew A.en_US
dc.contributor.authorCisneros, Brandon T.en_US
dc.contributor.authorShur, Michaelen_US
dc.contributor.authorGozin, Michaelen_US
dc.contributor.authorMcNally, Patrick J.en_US
dc.contributor.authorWilson, Lon J.en_US
dc.contributor.authorCurley, Steven A.en_US
dc.contributor.orgSmalley Institute for Nanoscale Science and Technologyen_US
dc.date.accessioned2015-01-05T20:03:21Z
dc.date.available2015-01-05T20:03:21Z
dc.date.issued2012en_US
dc.description.abstractThe evaluation of heat production from gold nanoparticles (AuNPs) irradiated with radio-frequency (RF) energy has been problematic due to Joule heating of their background ionic buffer suspensions. Insights into the physical heating mechanism of nanomaterials under RF excitations must be obtained if they are to have applications in fields such as nanoparticle-targeted hyperthermia for cancer therapy. By developing a purification protocol that allows for highly stable and concentrated solutions of citrate-capped AuNPs to be suspended in high-resistivity water, we show herein, for the first time, that heat production is only evident for AuNPs of diameters ≤10 nm, indicating a unique size-dependent heating behavior not previously observed. Heat production has also shown to be linearly dependent on both AuNP concentration and total surface area and was severely attenuated upon AuNP aggregation. These relationships have been further validated using permittivity analysis across a frequency range of 10 MHz–3 GHz as well as static conductivity measurements. Theoretical evaluations suggest that the heating mechanism can be modeled by the electrophoretic oscillation of charged AuNPs across finite length scales in response to a time-varying electric field. It is anticipated these results will assist future development of nanoparticle-assisted heat production by RF fields for applications such as targeted cancer hyperthermia.en_US
dc.identifier.citationCorr, Stuart J., Raoof, Mustafa, Mackeyev, Yuri, et al.. "Citrate-Capped Gold Nanoparticle Electrophoretic Heat Production in Response to a Time-Varying Radio-Frequency Electric Field." <i>The Journal of Physical Chemistry C,</i> 116, no. 45 (2012) American Chemical Society: 24380-24389. http://dx.doi.org/10.1021/jp309053z.
dc.identifier.doihttp://dx.doi.org/10.1021/jp309053zen_US
dc.identifier.urihttps://hdl.handle.net/1911/78852
dc.language.isoengen_US
dc.publisherAmerican Chemical Society
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.en_US
dc.subject.keywordradiofrequencyen_US
dc.subject.keywordgolden_US
dc.subject.keywordnanoparticlesen_US
dc.subject.keywordheatingen_US
dc.subject.keywordpermittivityen_US
dc.titleCitrate-Capped Gold Nanoparticle Electrophoretic Heat Production in Response to a Time-Varying Radio-Frequency Electric Fielden_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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