Distinct organization of two cortico-cortical feedback pathways

Simple item page
dc.citation.articleNumber6389en_US
dc.citation.journalTitleNature Communicationsen_US
dc.citation.volumeNumber13en_US
dc.contributor.authorShen, Shanen_US
dc.contributor.authorJiang, Xiaolongen_US
dc.contributor.authorScala, Federicoen_US
dc.contributor.authorFu, Jiakunen_US
dc.contributor.authorFahey, Paulen_US
dc.contributor.authorKobak, Dmitryen_US
dc.contributor.authorTan, Zhenghuanen_US
dc.contributor.authorZhou, Naen_US
dc.contributor.authorReimer, Jacoben_US
dc.contributor.authorSinz, Fabianen_US
dc.contributor.authorTolias, Andreas S.en_US
dc.date.accessioned2022-12-13T19:11:33Zen_US
dc.date.available2022-12-13T19:11:33Zen_US
dc.date.issued2022en_US
dc.description.abstractNeocortical feedback is critical for attention, prediction, and learning. To mechanically understand its function requires deciphering its cell-type wiring. Recent studies revealed that feedback between primary motor to primary somatosensory areas in mice is disinhibitory, targeting vasoactive intestinal peptide-expressing interneurons, in addition to pyramidal cells. It is unknown whether this circuit motif represents a general cortico-cortical feedback organizing principle. Here we show that in contrast to this wiring rule, feedback between higher-order lateromedial visual area to primary visual cortex preferentially activates somatostatin-expressing interneurons. Functionally, both feedback circuits temporally sharpen feed-forward excitation eliciting a transient increase–followed by a prolonged decrease–in pyramidal cell activity under sustained feed-forward input. However, under feed-forward transient input, the primary motor to primary somatosensory cortex feedback facilitates bursting while lateromedial area to primary visual cortex feedback increases time precision. Our findings argue for multiple cortico-cortical feedback motifs implementing different dynamic non-linear operations.en_US
dc.identifier.citationShen, Shan, Jiang, Xiaolong, Scala, Federico, et al.. "Distinct organization of two cortico-cortical feedback pathways." <i>Nature Communications,</i> 13, (2022) Springer Nature: https://doi.org/10.1038/s41467-022-33883-9.en_US
dc.identifier.digitals41467-022-33883-9en_US
dc.identifier.doihttps://doi.org/10.1038/s41467-022-33883-9en_US
dc.identifier.urihttps://hdl.handle.net/1911/114118en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleDistinct organization of two cortico-cortical feedback pathwaysen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
s41467-022-33883-9.pdf
Size:
5.71 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
ECE Publications