Surfactant-free Gd3+-ion-containing carbon nanotube MRI contrast agents for stem cell labeling

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dc.citation.firstpage12085en_US
dc.citation.journalTitleNanoscaleen_US
dc.citation.lastpage12091en_US
dc.citation.volumeNumber7en_US
dc.contributor.authorGizzatov, Ayraten_US
dc.contributor.authorHernández-Rivera, Mayraen_US
dc.contributor.authorKeshishian, Vazriken_US
dc.contributor.authorMackeyev, Yurien_US
dc.contributor.authorLaw, Justin J.en_US
dc.contributor.authorGuven, Ademen_US
dc.contributor.authorSethi, Richaen_US
dc.contributor.authorQu, Feifeien_US
dc.contributor.authorMuthupillai, Rajaen_US
dc.contributor.authorCabreira-Hansen, Maria da Graçaen_US
dc.contributor.authorWillerson, James T.en_US
dc.contributor.authorPerin, Emerson C.en_US
dc.contributor.authorMa, Qingen_US
dc.contributor.authorBryant, Robert G.en_US
dc.contributor.authorWilson, Lon J.en_US
dc.contributor.orgRichard E. Smalley Institute for Nanoscale Science and Technologyen_US
dc.date.accessioned2015-10-30T15:40:41Zen_US
dc.date.available2015-10-30T15:40:41Zen_US
dc.date.issued2015en_US
dc.description.abstractThere is an ever increasing interest in developing new stem cell therapies. However, imaging and tracking stem cells in vivo after transplantation remains a serious challenge. In this work, we report new, functionalized and high-performance Gd3+-ion-containing ultra-short carbon nanotube (US-tube) MRI contrast agent (CA) materials which are highly-water-dispersible (ca. 35 mg ml−1) without the need of a surfactant. The new materials have extremely high T1-weighted relaxivities of 90 (mM s)−1 per Gd3+ ion at 1.5 T at room temperature and have been used to safely label porcine bone-marrow-derived mesenchymal stem cells for MR imaging. The labeled cells display excellent image contrast in phantom imaging experiments, and TEM images of the labeled cells, in general, reveal small clusters of the CA material located within the cytoplasm with 109 Gd3+ ions per cell.en_US
dc.identifier.citationGizzatov, Ayrat, Hernández-Rivera, Mayra, Keshishian, Vazrik, et al.. "Surfactant-free Gd3+-ion-containing carbon nanotube MRI contrast agents for stem cell labeling." <i>Nanoscale,</i> 7, (2015) Royal Society of Chemistry: 12085-12091. http://dx.doi.org/10.1039/C5NR02078F.en_US
dc.identifier.doihttp://dx.doi.org/10.1039/C5NR02078Fen_US
dc.identifier.urihttps://hdl.handle.net/1911/82003en_US
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsThis Open Access Article is licensed under a Creative Commons Attribution 3.0 Unported Licence.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/en_US
dc.titleSurfactant-free Gd3+-ion-containing carbon nanotube MRI contrast agents for stem cell labelingen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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