Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins

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dc.citation.firstpage24669en_US
dc.citation.journalTitleThe Journal of Biological Chemistryen_US
dc.citation.lastpage24677en_US
dc.citation.volumeNumber290en_US
dc.contributor.authorBondos, Sarah E.en_US
dc.contributor.authorSwint-Kruse, Liskinen_US
dc.contributor.authorMatthews, Kathleen S.en_US
dc.date.accessioned2015-10-12T15:47:24Zen_US
dc.date.available2015-10-12T15:47:24Zen_US
dc.date.issued2015en_US
dc.description.abstractTo modulate transcription, a variety of input signals must be sensed by genetic regulatory proteins. In these proteins, flexibility and disorder are emerging as common themes. Prokaryotic regulators generally have short, flexible segments, whereas eukaryotic regulators have extended regions that lack predicted secondary structure (intrinsic disorder). Two examples illustrate the impact of flexibility and disorder on gene regulation: the prokaryotic LacI/GalR family, with detailed information from studies on LacI, and the eukaryotic family of Hox proteins, with specific insights from investigations of Ultrabithorax (Ubx). The widespread importance of structural disorder in gene regulatory proteins may derive from the need for flexibility in signal response and, particularly in eukaryotes, in protein partner selection.en_US
dc.identifier.citationBondos, Sarah E., Swint-Kruse, Liskin and Matthews, Kathleen S.. "Flexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteins." <i>The Journal of Biological Chemistry,</i> 290, (2015) American Society for Biochemistry and Molecular Biology: 24669-24677. http://dx.doi.org/10.1074/jbc.R115.685032.en_US
dc.identifier.doihttp://dx.doi.org/10.1074/jbc.R115.685032en_US
dc.identifier.urihttps://hdl.handle.net/1911/81874en_US
dc.language.isoengen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biologyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Society for Biochemistry and Molecular Biology.en_US
dc.subject.keywordDNAen_US
dc.subject.keywordDNA operatoren_US
dc.subject.keywordDNA-binding proteinen_US
dc.subject.keywordHox proteinsen_US
dc.subject.keywordLacI/GalR proteinsen_US
dc.subject.keywordUltrabithoraxen_US
dc.subject.keywordgene regulationen_US
dc.subject.keywordintrinsic disorderen_US
dc.subject.keywordprotein flexibilityen_US
dc.subject.keywordrepressor proteinen_US
dc.subject.keywordtranscription factoren_US
dc.titleFlexibility and Disorder in Gene Regulation: LacI/GalR and Hox Proteinsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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