Synthesis and Characterization of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering
dc.citation.firstpage | 1908 | en_US |
dc.citation.issueNumber | 6 | en_US |
dc.citation.journalTitle | Biomacromolecules | en_US |
dc.citation.lastpage | 1915 | en_US |
dc.citation.volumeNumber | 13 | en_US |
dc.contributor.author | Ekenseair, Adam K. | en_US |
dc.contributor.author | Boere, Kristel W.M. | en_US |
dc.contributor.author | Tzouanas, Stephanie N. | en_US |
dc.contributor.author | Vo, Tiffany N. | en_US |
dc.contributor.author | Kasper, F. Kurtis | en_US |
dc.contributor.author | Mikos, Antonios G. | en_US |
dc.date.accessioned | 2013-08-20T22:04:31Z | en_US |
dc.date.available | 2013-08-20T22:04:31Z | en_US |
dc.date.issued | 2012 | en_US |
dc.description.abstract | Novel, injectable hydrogels were developed that solidify through a dual-gelation, physical and chemical, mechanism upon preparation and elevation of temperature to 37°C. A thermogelling, poly(N-isopropylacrylamide)-based macromer with pendant epoxy rings and a hydrolyticallydegradable polyamidoamine-based diamine crosslinker were synthesized, characterized, and combined to produce in situ forming hydrogel constructs. Network formation through the epoxyamine reaction was shown to be rapid and facile, and the progressive incorporation of the hydrophilic polyamidoamine crosslinker into the hydrogel was shown to mitigate the often problematic tendency of thermogelling materials to undergo significant post-formation gel syneresis. The results suggest that this novel class of injectable hydrogels may be attractive substrates for tissue engineering applications due to the synthetic versatility of the component materials and beneficial hydrogel gelation kinetics and stability. | en_US |
dc.embargo.terms | none | en_US |
dc.identifier.citation | Ekenseair, Adam K., Boere, Kristel W.M., Tzouanas, Stephanie N., et al.. "Synthesis and Characterization of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering." <i>Biomacromolecules,</i> 13, no. 6 (2012) American Chemical Society: 1908-1915. http://dx.doi.org/10.1021/bm300429e. | en_US |
dc.identifier.doi | http://dx.doi.org/10.1021/bm300429e | en_US |
dc.identifier.uri | https://hdl.handle.net/1911/71745 | en_US |
dc.language.iso | eng | en_US |
dc.publisher | American Chemical Society | en_US |
dc.rights | This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society. | en_US |
dc.subject.keyword | poly(N-isopropylacrylamide) | en_US |
dc.subject.keyword | polyamidoamine | en_US |
dc.subject.keyword | tissue engineering | en_US |
dc.subject.keyword | injectable | en_US |
dc.subject.keyword | hydrogel | en_US |
dc.title | Synthesis and Characterization of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering | en_US |
dc.type | Journal article | en_US |
dc.type.dcmi | Text | en_US |
dc.type.publication | post-print | en_US |