Synthesis and Characterization of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering

dc.citation.firstpage1908en_US
dc.citation.issueNumber6en_US
dc.citation.journalTitleBiomacromoleculesen_US
dc.citation.lastpage1915en_US
dc.citation.volumeNumber13en_US
dc.contributor.authorEkenseair, Adam K.en_US
dc.contributor.authorBoere, Kristel W.M.en_US
dc.contributor.authorTzouanas, Stephanie N.en_US
dc.contributor.authorVo, Tiffany N.en_US
dc.contributor.authorKasper, F. Kurtisen_US
dc.contributor.authorMikos, Antonios G.en_US
dc.date.accessioned2013-08-20T22:04:31Zen_US
dc.date.available2013-08-20T22:04:31Zen_US
dc.date.issued2012en_US
dc.description.abstractNovel, injectable hydrogels were developed that solidify through a dual-gelation, physical and chemical, mechanism upon preparation and elevation of temperature to 37°C. A thermogelling, poly(N-isopropylacrylamide)-based macromer with pendant epoxy rings and a hydrolyticallydegradable polyamidoamine-based diamine crosslinker were synthesized, characterized, and combined to produce in situ forming hydrogel constructs. Network formation through the epoxyamine reaction was shown to be rapid and facile, and the progressive incorporation of the hydrophilic polyamidoamine crosslinker into the hydrogel was shown to mitigate the often problematic tendency of thermogelling materials to undergo significant post-formation gel syneresis. The results suggest that this novel class of injectable hydrogels may be attractive substrates for tissue engineering applications due to the synthetic versatility of the component materials and beneficial hydrogel gelation kinetics and stability.en_US
dc.embargo.termsnoneen_US
dc.identifier.citationEkenseair, Adam K., Boere, Kristel W.M., Tzouanas, Stephanie N., et al.. "Synthesis and Characterization of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineering." <i>Biomacromolecules,</i> 13, no. 6 (2012) American Chemical Society: 1908-1915. http://dx.doi.org/10.1021/bm300429e.en_US
dc.identifier.doihttp://dx.doi.org/10.1021/bm300429een_US
dc.identifier.urihttps://hdl.handle.net/1911/71745en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.en_US
dc.subject.keywordpoly(N-isopropylacrylamide)en_US
dc.subject.keywordpolyamidoamineen_US
dc.subject.keywordtissue engineeringen_US
dc.subject.keywordinjectableen_US
dc.subject.keywordhydrogelen_US
dc.titleSynthesis and Characterization of Thermally and Chemically Gelling Injectable Hydrogels for Tissue Engineeringen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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