Open-Source Selective Laser Sintering (OpenSLS) of Nylon and Biocompatible Polycaprolactone

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dc.citation.firstpagee0147399en_US
dc.citation.issueNumber2en_US
dc.citation.journalTitlePLoS ONEen_US
dc.citation.volumeNumber11en_US
dc.contributor.authorKinstlinger, Ian S.en_US
dc.contributor.authorBastian, Andreasen_US
dc.contributor.authorPaulsen, Samantha J.en_US
dc.contributor.authorHwang, Daniel H.en_US
dc.contributor.authorTa, Anderson H.en_US
dc.contributor.authorYalacki, David R.en_US
dc.contributor.authorSchmidt, Timen_US
dc.contributor.authorMiller, Jordan S.en_US
dc.date.accessioned2016-04-04T20:15:21Zen_US
dc.date.available2016-04-04T20:15:21Zen_US
dc.date.issued2016en_US
dc.description.abstractSelective Laser Sintering (SLS) is an additive manufacturing process that uses a laser to fuse powdered starting materials into solid 3D structures. Despite the potential for fabrication of complex, high-resolution structures with SLS using diverse starting materials (including biomaterials), prohibitive costs of commercial SLS systems have hindered the wide adoption of this technology in the scientific community. Here, we developed a low-cost, open-source SLS system (OpenSLS) and demonstrated its capacity to fabricate structures in nylon with sub-millimeter features and overhanging regions. Subsequently, we demonstrated fabrication of polycaprolactone (PCL) into macroporous structures such as a diamond lattice. Widespread interest in using PCL for bone tissue engineering suggests that PCL lattices are relevant model scaffold geometries for engineering bone. SLS of materials with large powder grain size (~500 μm) leads to part surfaces with high roughness, so we further introduced a simple vapor-smoothing technique to reduce the surface roughness of sintered PCL structures which further improves their elastic modulus and yield stress. Vapor-smoothed PCL can also be used for sacrificial templating of perfusable fluidic networks within orthogonal materials such as poly(dimethylsiloxane) silicone. Finally, we demonstrated that human mesenchymal stem cells were able to adhere, survive, and differentiate down an osteogenic lineage on sintered and smoothed PCL surfaces, suggesting that OpenSLS has the potential to produce PCL scaffolds useful for cell studies. OpenSLS provides the scientific community with an accessible platform for the study of laser sintering and the fabrication of complex geometries in diverse materials.en_US
dc.identifier.citationKinstlinger, Ian S., Bastian, Andreas, Paulsen, Samantha J., et al.. "Open-Source Selective Laser Sintering (OpenSLS) of Nylon and Biocompatible Polycaprolactone." <i>PLoS ONE,</i> 11, no. 2 (2016) Public Library of Science: e0147399. http://dx.doi.org/10.1371/journal.pone.0147399.en_US
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0147399en_US
dc.identifier.urihttps://hdl.handle.net/1911/88837en_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsThis is an open access article distributed under the terms of theﾠCreative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleOpen-Source Selective Laser Sintering (OpenSLS) of Nylon and Biocompatible Polycaprolactoneen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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