Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging

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dc.citation.articleNumber164en_US
dc.citation.journalTitleCommunications Materialsen_US
dc.citation.volumeNumber5en_US
dc.contributor.authorLoh, Kang Yongen_US
dc.contributor.authorLi, Lei S.en_US
dc.contributor.authorFan, Jingyueen_US
dc.contributor.authorGoh, Yi Yiingen_US
dc.contributor.authorLiew, Weng Hengen_US
dc.contributor.authorDavis, Samuelen_US
dc.contributor.authorZhang, Yideen_US
dc.contributor.authorLi, Kaien_US
dc.contributor.authorLiu, Jieen_US
dc.contributor.authorLiang, Liangliangen_US
dc.contributor.authorFeng, Minjunen_US
dc.contributor.authorYang, Mingen_US
dc.contributor.authorZhang, Hangen_US
dc.contributor.authorMa, Ping’anen_US
dc.contributor.authorFeng, Guangxueen_US
dc.contributor.authorMu, Zhaoen_US
dc.contributor.authorGao, Weiboen_US
dc.contributor.authorSum, Tze Chienen_US
dc.contributor.authorLiu, Binen_US
dc.contributor.authorLin, Junen_US
dc.contributor.authorYao, Kuien_US
dc.contributor.authorWang, Lihong V.en_US
dc.contributor.authorLiu, Xiaogangen_US
dc.date.accessioned2024-10-08T13:27:49Zen_US
dc.date.available2024-10-08T13:27:49Zen_US
dc.date.issued2024en_US
dc.description.abstractPhotoacoustic tomography offers a powerful tool to visualize biologically relevant molecules and understand processes within living systems at high resolution in deep tissue, facilitated by the conversion of incident photons into low-scattering acoustic waves through non-radiative relaxation. Although current endogenous and exogenous photoacoustic contrast agents effectively enable molecular imaging within deep tissues, their broad absorption spectra in the visible to near-infrared (NIR) range limit photoacoustic multiplexed imaging. Here, we exploit the distinct ultrasharp NIR absorption peaks of lanthanides to engineer a series of NIR photoacoustic nanocrystals. This engineering involves precise host and dopant material composition, yielding nanocrystals with sharply peaked photoacoustic absorption spectra (~3.2 nm width) and a ~10-fold enhancement in NIR optical absorption for efficient deep tissue imaging. By combining photoacoustic tomography with these engineered nanocrystals, we demonstrate photoacoustic multiplexed differential imaging with substantially decreased background signals and enhanced precision and contrast.en_US
dc.identifier.citationLoh, K. Y., Li, L. S., Fan, J., Goh, Y. Y., Liew, W. H., Davis, S., Zhang, Y., Li, K., Liu, J., Liang, L., Feng, M., Yang, M., Zhang, H., Ma, P., Feng, G., Mu, Z., Gao, W., Sum, T. C., Liu, B., … Liu, X. (2024). Sharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imaging. Communications Materials, 5(1), 1–10. https://doi.org/10.1038/s43246-024-00605-1en_US
dc.identifier.digitals43246-024-00605-1en_US
dc.identifier.doihttps://doi.org/10.1038/s43246-024-00605-1en_US
dc.identifier.urihttps://hdl.handle.net/1911/117926en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleSharp-peaked lanthanide nanocrystals for near-infrared photoacoustic multiplexed differential imagingen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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