Salivary biomarkers associated with myocardial necrosis: results from an alcohol septal ablation model

Simple item page
dc.citation.firstpage616
dc.citation.issueNumber5
dc.citation.journalTitleOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
dc.citation.lastpage623
dc.citation.volumeNumber114
dc.contributor.authorFoley, Joseph D. III
dc.contributor.authorSneed, J. Darrell
dc.contributor.authorSteinhubl, Steven R.
dc.contributor.authorKolasa, Justin R.
dc.contributor.authorEbersole, Jeffrey L.
dc.contributor.authorLin, Yushun
dc.contributor.authorKryscio, Richard J.
dc.contributor.authorMcDevitt, John T.
dc.contributor.authorCampbell, Charles L.
dc.contributor.authorMiller, Craig S.
dc.date.accessioned2017-08-02T14:52:15Z
dc.date.available2017-08-02T14:52:15Z
dc.date.issued2012
dc.description.abstractObjective: To determine if salivary biomarkers demonstrate utility for identifying aspects of myocardial necrosis. Methods: Twenty-one patients undergoing alcohol septal ablation (ASA) for treatment of hypertrophic cardiomyopathy provided serum and unstimulated whole saliva at baseline and incremental time points post-ASA. Samples were analyzed for seven biomarkers related to myocardial damage, inflammation, and tissue remodeling using immunosorbent assays. Levels were compared with baseline and levels observed in 97 healthy controls. Results: Biomarkers of myocardial damage and inflammation (ie, troponin I, creatine kinase-MB, myoglobin, C-reactive protein) rose in serum 2- to 812-fold after ASA (P < .01). Significant elevations of 2.0- to 3.5-fold were observed with C-reactive protein and troponin I in saliva (P < .02). Significant correlations between levels in serum and saliva were observed for C-reactive protein, matrix metalloproteinase-9, and myeloperoxidase (P < .001). Conclusions: Select salivary biomarkers reflect changes that occur during, and subsequent to, myocardial necrosis caused by ASA.
dc.identifier.citationFoley, Joseph D. III, Sneed, J. Darrell, Steinhubl, Steven R., et al.. "Salivary biomarkers associated with myocardial necrosis: results from an alcohol septal ablation model." <i>Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology,</i> 114, no. 5 (2012) Elsevier: 616-623. https://doi.org/10.1016/j.oooo.2012.05.024.
dc.identifier.digitalSalivary_Biomarkers
dc.identifier.doihttps://doi.org/10.1016/j.oooo.2012.05.024
dc.identifier.urihttps://hdl.handle.net/1911/96165
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.titleSalivary biomarkers associated with myocardial necrosis: results from an alcohol septal ablation model
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Salivary_Biomarkers.pdf
Size:
1.11 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Chemistry Publications