Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents

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dc.contributor.assigneeRice Universityen_US
dc.contributor.assigneeBRISTOL-MYERS SQUIBB COMPANYen_US
dc.contributor.assigneeThe Scripps Research Instituteen_US
dc.contributor.publisherUnited States Patent and Trademark Officeen_US
dc.creatorNicolaou, Kyriacos C.en_US
dc.creatorLu, Minen_US
dc.creatorMandal, Debashisen_US
dc.creatorGangwar, Sanjeeven_US
dc.creatorChowdari, Naidu S.en_US
dc.creatorPoudel, Yam B.en_US
dc.date.accessioned2021-03-02T23:43:39Zen_US
dc.date.available2021-03-02T23:43:39Zen_US
dc.date.filed2019-03-08en_US
dc.date.issued2021-01-12en_US
dc.description.abstractIn one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.en_US
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposesen_US
dc.format.extent103en_US
dc.identifier.citationNicolaou, Kyriacos C., Lu, Min, Mandal, Debashis, Gangwar, Sanjeev, Chowdari, Naidu S. and Poudel, Yam B., "Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents." Patent US10889590B2. issued 2021-01-12. Retrieved from <a href="https://hdl.handle.net/1911/110128">https://hdl.handle.net/1911/110128</a>.en_US
dc.identifier.patentIDUS10889590B2en_US
dc.identifier.urihttps://hdl.handle.net/1911/110128en_US
dc.language.isoengen_US
dc.titleDerivatives of uncialamycin, methods of synthesis and their use as antitumor agentsen_US
dc.typeUtility patenten_US
dc.type.dcmiTexten_US
dc.type.genrepatentsen_US
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