Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents

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dc.contributor.assigneeRice University
dc.contributor.assigneeBRISTOL-MYERS SQUIBB COMPANY
dc.contributor.assigneeThe Scripps Research Institute
dc.contributor.publisherUnited States Patent and Trademark Office
dc.creatorNicolaou, Kyriacos C.
dc.creatorLu, Min
dc.creatorMandal, Debashis
dc.creatorGangwar, Sanjeev
dc.creatorChowdari, Naidu S.
dc.creatorPoudel, Yam B.
dc.date.accessioned2021-03-02T23:43:39Z
dc.date.available2021-03-02T23:43:39Z
dc.date.filed2019-03-08
dc.date.issued2021-01-12
dc.description.abstractIn one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes
dc.format.extent103
dc.identifier.citationNicolaou, Kyriacos C., Lu, Min, Mandal, Debashis, Gangwar, Sanjeev, Chowdari, Naidu S. and Poudel, Yam B., "Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents." Patent US10889590B2. issued 2021-01-12. Retrieved from <a href="https://hdl.handle.net/1911/110128">https://hdl.handle.net/1911/110128</a>.
dc.identifier.patentIDUS10889590B2
dc.identifier.urihttps://hdl.handle.net/1911/110128
dc.language.isoeng
dc.titleDerivatives of uncialamycin, methods of synthesis and their use as antitumor agents
dc.typeUtility patent
dc.type.dcmiText
dc.type.genrepatents
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