Total Synthesis of Δ12-Prostaglandin J3, a Highly Potent and Selective Antileukemic Agent
| dc.citation.firstpage | 10611 | en_US |
| dc.citation.issueNumber | 39 | en_US |
| dc.citation.journalTitle | Angewandte Chemie | en_US |
| dc.citation.lastpage | 10615 | en_US |
| dc.citation.volumeNumber | 126 | en_US |
| dc.contributor.author | Nicolaou, K.C. | en_US |
| dc.contributor.author | Heretsch, Philipp | en_US |
| dc.contributor.author | ElMarrouni, Abdelatif | en_US |
| dc.contributor.author | Hale, Christopher R.H. | en_US |
| dc.contributor.author | Pulukuri, Kiran K. | en_US |
| dc.contributor.author | Kudva, Avinash K. | en_US |
| dc.contributor.author | Narayan, Vivek | en_US |
| dc.contributor.author | Prabhu, K. Sandeep | en_US |
| dc.contributor.org | BioScience Research Collaborative | en_US |
| dc.date.accessioned | 2015-10-29T18:23:24Z | |
| dc.date.available | 2015-10-29T18:23:24Z | |
| dc.date.issued | 2014 | en_US |
| dc.description.abstract | A catalytic asymmetric total synthesis of the potent and selective antileukemic Δ12-prostaglandin J3 (Δ12-PGJ3) is described. The convergent synthesis proceeded through intermediates 2 and 3, constructed enantioselectively from readily available starting materials and coupled through an aldol reaction followed by dehydration to afford stereoselectively the cyclopentenone alkylidene structural motif of the molecule. | en_US |
| dc.identifier.citation | Nicolaou, K.C., Heretsch, Philipp, ElMarrouni, Abdelatif, et al.. "Total Synthesis of Δ12-Prostaglandin J3, a Highly Potent and Selective Antileukemic Agent." <i>Angewandte Chemie,</i> 126, no. 39 (2014) Wiley: 10611-10615. http://dx.doi.org/10.1002/ange.201404917. | |
| dc.identifier.doi | http://dx.doi.org/10.1002/ange.201404917 | en_US |
| dc.identifier.uri | https://hdl.handle.net/1911/81982 | |
| dc.language.iso | eng | en_US |
| dc.publisher | Wiley | |
| dc.rights | This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley. | en_US |
| dc.subject.keyword | asymmetric catalysis | en_US |
| dc.subject.keyword | C-H activation | en_US |
| dc.subject.keyword | leukemia | en_US |
| dc.subject.keyword | natural products | en_US |
| dc.subject.keyword | total synthesis | en_US |
| dc.title | Total Synthesis of Δ12-Prostaglandin J3, a Highly Potent and Selective Antileukemic Agent | en_US |
| dc.type | Journal article | en_US |
| dc.type.dcmi | Text | en_US |
| dc.type.publication | post-print | en_US |