Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse

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dc.citation.firstpage47en_US
dc.citation.journalTitleCancer Nanotechnologyen_US
dc.citation.lastpage54en_US
dc.citation.volumeNumber3en_US
dc.contributor.authorChoi, Mi-Ranen_US
dc.contributor.authorBardhan, Riziaen_US
dc.contributor.authorStanton-Maxey, Katie J.en_US
dc.contributor.authorBadve, Sunilen_US
dc.contributor.authorNakshatri, Harikrishnaen_US
dc.contributor.authorStantz, Keith M.en_US
dc.contributor.authorCao, Ningen_US
dc.contributor.authorHalas, Naomi J.en_US
dc.contributor.authorClare, Susan E.en_US
dc.contributor.orgLaboratory for Nanophotonicsen_US
dc.date.accessioned2013-03-14T17:11:55Zen_US
dc.date.available2013-03-14T17:11:55Zen_US
dc.date.issued2012en_US
dc.description.abstractAs systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood-brain barrier (BBB) represents a major challenge to the delivery of therapeutics to the brain. Macrophages originating from circulating monocytes are able to infiltrate brain metastases while the BBB is intact. Here, we show that this ability can be exploited to deliver both diagnostic and therapeutic nanoparticles specifically to experimental brain metastases of breast cancer.en_US
dc.embargo.termsnoneen_US
dc.identifier.citationChoi, Mi-Ran, Bardhan, Rizia, Stanton-Maxey, Katie J., et al.. "Delivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horse." <i>Cancer Nanotechnology,</i> 3, (2012) Springer: 47-54. http://dx.doi.org/10.1007/s12645-012-0029-9.en_US
dc.identifier.doihttp://dx.doi.org/10.1007/s12645-012-0029-9en_US
dc.identifier.urihttps://hdl.handle.net/1911/70591en_US
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.subject.keywordbreast canceren_US
dc.subject.keywordbrain metastasisen_US
dc.subject.keywordgold-silica nanoshellen_US
dc.subject.keywordnanoparticleen_US
dc.subject.keywordblood-brain barrieren_US
dc.titleDelivery of nanoparticles to brain metastases of breast cancer using a cellular Trojan horseen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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