Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve

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dc.citation.articleNumber1539en_US
dc.citation.journalTitleNature Communicationsen_US
dc.citation.volumeNumber12en_US
dc.contributor.authorMridha, Zakiren_US
dc.contributor.authorde Gee, Jan Willemen_US
dc.contributor.authorShi, Yanchenen_US
dc.contributor.authorAlkashgari, Rayanen_US
dc.contributor.authorWilliams, Justinen_US
dc.contributor.authorSuminski, Aaronen_US
dc.contributor.authorWard, Matthew P.en_US
dc.contributor.authorZhang, Wenhaoen_US
dc.contributor.authorMcGinley, Matthew Jamesen_US
dc.date.accessioned2021-04-21T15:46:26Zen_US
dc.date.available2021-04-21T15:46:26Zen_US
dc.date.issued2021en_US
dc.description.abstractVagus nerve stimulation (VNS) is thought to affect neural activity by recruiting brain-wide release of neuromodulators. VNS is used in treatment-resistant epilepsy, and is increasingly being explored for other disorders, such as depression, and as a cognitive enhancer. However, the promise of VNS is only partially fulfilled due to a lack of mechanistic understanding of the transfer function between stimulation parameters and neuromodulatory response, together with a lack of biosensors for assaying stimulation efficacy in real time. We here develop an approach to VNS in head-fixed mice on a treadmill and show that pupil dilation is a reliable and convenient biosensor for VNS-evoked cortical neuromodulation. In an ‘optimal’ zone of stimulation parameters, current leakage and off-target effects are minimized and the extent of pupil dilation tracks VNS-evoked basal-forebrain cholinergic axon activity in neocortex. Thus, pupil dilation is a sensitive readout of the moment-by-moment, titratable effects of VNS on brain state.en_US
dc.identifier.citationMridha, Zakir, de Gee, Jan Willem, Shi, Yanchen, et al.. "Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve." <i>Nature Communications,</i> 12, (2021) Springer Nature: https://doi.org/10.1038/s41467-021-21730-2.en_US
dc.identifier.digitals41467-021-21730-2en_US
dc.identifier.doihttps://doi.org/10.1038/s41467-021-21730-2en_US
dc.identifier.urihttps://hdl.handle.net/1911/110308en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleGraded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerveen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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