Whole genome analysis of clouded leopard species reveals an ancient divergence and distinct demographic histories

dc.citation.articleNumber105647
dc.citation.issueNumber12
dc.citation.journalTitleiScience
dc.citation.volumeNumber25
dc.contributor.authorBursell, Madeline G.
dc.contributor.authorDikow, Rebecca B.
dc.contributor.authorFigueiró, Henrique V.
dc.contributor.authorDudchenko, Olga
dc.contributor.authorFlanagan, Joseph P.
dc.contributor.authorAiden, Erez Lieberman
dc.contributor.authorGoossens, Benoit
dc.contributor.authorNathan, Senthilvel K. S. S.
dc.contributor.authorJohnson, Warren E.
dc.contributor.authorKoepfli, Klaus-Peter
dc.contributor.authorFrandsen, Paul B.
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2023-01-27T14:47:08Z
dc.date.available2023-01-27T14:47:08Z
dc.date.issued2022
dc.description.abstractSimilar to other apex predator species, populations of mainland (Neofelis nebulosa) and Sunda (Neofelis diardi) clouded leopards are declining. Understanding their patterns of genetic variation can provide critical insights on past genetic erosion and a baseline for understanding their long-term conservation needs. As a step toward this goal, we present draft genome assemblies for the two clouded leopard species to quantify their phylogenetic divergence, genome-wide diversity, and historical population trends. We estimate that the two species diverged 5.1 Mya, much earlier than previous estimates of 1.41 Mya and 2.86 Mya, suggesting they separated when Sundaland was becoming increasingly isolated from mainland Southeast Asia. The Sunda clouded leopard displays a distinct and reduced effective population size trajectory, consistent with a lower genome-wide heterozygosity and SNP density, relative to the mainland clouded leopard. Our results provide new insights into the evolutionary history and genetic health of this unique lineage of felids.
dc.identifier.citationBursell, Madeline G., Dikow, Rebecca B., Figueiró, Henrique V., et al.. "Whole genome analysis of clouded leopard species reveals an ancient divergence and distinct demographic histories." <i>iScience,</i> 25, no. 12 (2022) Cell Press: https://doi.org/10.1016/j.isci.2022.105647.
dc.identifier.digital1-s2-0-S2589004222019198-main
dc.identifier.doihttps://doi.org/10.1016/j.isci.2022.105647
dc.identifier.urihttps://hdl.handle.net/1911/114247
dc.language.isoeng
dc.publisherCell Press
dc.rightsThis is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/).
dc.titleWhole genome analysis of clouded leopard species reveals an ancient divergence and distinct demographic histories
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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