Whole genome analysis of clouded leopard species reveals an ancient divergence and distinct demographic histories

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dc.citation.articleNumber105647en_US
dc.citation.issueNumber12en_US
dc.citation.journalTitleiScienceen_US
dc.citation.volumeNumber25en_US
dc.contributor.authorBursell, Madeline G.en_US
dc.contributor.authorDikow, Rebecca B.en_US
dc.contributor.authorFigueiró, Henrique V.en_US
dc.contributor.authorDudchenko, Olgaen_US
dc.contributor.authorFlanagan, Joseph P.en_US
dc.contributor.authorAiden, Erez Liebermanen_US
dc.contributor.authorGoossens, Benoiten_US
dc.contributor.authorNathan, Senthilvel K. S. S.en_US
dc.contributor.authorJohnson, Warren E.en_US
dc.contributor.authorKoepfli, Klaus-Peteren_US
dc.contributor.authorFrandsen, Paul B.en_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2023-01-27T14:47:08Zen_US
dc.date.available2023-01-27T14:47:08Zen_US
dc.date.issued2022en_US
dc.description.abstractSimilar to other apex predator species, populations of mainland (Neofelis nebulosa) and Sunda (Neofelis diardi) clouded leopards are declining. Understanding their patterns of genetic variation can provide critical insights on past genetic erosion and a baseline for understanding their long-term conservation needs. As a step toward this goal, we present draft genome assemblies for the two clouded leopard species to quantify their phylogenetic divergence, genome-wide diversity, and historical population trends. We estimate that the two species diverged 5.1 Mya, much earlier than previous estimates of 1.41 Mya and 2.86 Mya, suggesting they separated when Sundaland was becoming increasingly isolated from mainland Southeast Asia. The Sunda clouded leopard displays a distinct and reduced effective population size trajectory, consistent with a lower genome-wide heterozygosity and SNP density, relative to the mainland clouded leopard. Our results provide new insights into the evolutionary history and genetic health of this unique lineage of felids.en_US
dc.identifier.citationBursell, Madeline G., Dikow, Rebecca B., Figueiró, Henrique V., et al.. "Whole genome analysis of clouded leopard species reveals an ancient divergence and distinct demographic histories." <i>iScience,</i> 25, no. 12 (2022) Cell Press: https://doi.org/10.1016/j.isci.2022.105647.en_US
dc.identifier.digital1-s2-0-S2589004222019198-mainen_US
dc.identifier.doihttps://doi.org/10.1016/j.isci.2022.105647en_US
dc.identifier.urihttps://hdl.handle.net/1911/114247en_US
dc.language.isoengen_US
dc.publisherCell Pressen_US
dc.rightsThis is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/).en_US
dc.titleWhole genome analysis of clouded leopard species reveals an ancient divergence and distinct demographic historiesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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