Adsorption of a Protein Monolayer via Hydrophobic Interactions Prevents Nanoparticle Aggregation under Harsh Environmental Conditions

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dc.citation.firstpage833en_US
dc.citation.issueNumber7en_US
dc.citation.journalTitleACS Sustainable Chemistry & Engineeringen_US
dc.citation.lastpage842en_US
dc.citation.volumeNumber1en_US
dc.contributor.authorDominguez-Medina, Sergioen_US
dc.contributor.authorBlankenburg, Janen_US
dc.contributor.authorOlson, Janaen_US
dc.contributor.authorLandes, Christy F.en_US
dc.contributor.authorLink, Stephanen_US
dc.contributor.orgLaboratory for Nanophotonicsen_US
dc.date.accessioned2014-10-06T17:18:02Zen_US
dc.date.available2014-10-06T17:18:02Zen_US
dc.date.issued2013en_US
dc.description.abstractWe find that citrate-stabilized gold nanoparticles aggregate and precipitate in saline solutions below the NaCl concentration of many bodily fluids and blood plasma. Our experiments indicate that this is due to complexation of the citrate anions with Na+ cations in solution. A dramatically enhanced colloidal stability is achieved when bovine serum albumin is adsorbed to the gold nanoparticle surface, completely preventing nanoparticle aggregation under harsh environmental conditions where the NaCl concentration is well beyond the isotonic point. Furthermore, we explore the mechanism of the formation of this albumin "corona" and find that monolayer protein adsorption is most likely ruled by hydrophobic interactions. As for many nanotechnology-based biomedical and environmental applications, particle aggregation and sedimentation are undesirable and could substantially increase the risk of toxicological side-effects, the formation of the BSA corona presented here provides a low-cost bio-compatible strategy for nanoparticle stabilization and transport in highly ionic environments.en_US
dc.identifier.citationDominguez-Medina, Sergio, Blankenburg, Jan, Olson, Jana, et al.. "Adsorption of a Protein Monolayer via Hydrophobic Interactions Prevents Nanoparticle Aggregation under Harsh Environmental Conditions." <i>ACS Sustainable Chemistry & Engineering,</i> 1, no. 7 (2013) American Chemical Society: 833-842. http://dx.doi.org/10.1021/sc400042h.en_US
dc.identifier.doihttp://dx.doi.org/10.1021/sc400042hen_US
dc.identifier.urihttps://hdl.handle.net/1911/77401en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.en_US
dc.subject.keywordgold nanoparticlesen_US
dc.subject.keywordsurface plasmonen_US
dc.subject.keywordbovine serum albuminen_US
dc.subject.keywordprotein coronaen_US
dc.subject.keywordcorrelation spectroscopyen_US
dc.subject.keyworddiffusionen_US
dc.titleAdsorption of a Protein Monolayer via Hydrophobic Interactions Prevents Nanoparticle Aggregation under Harsh Environmental Conditionsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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