The Genome of the Ctenophore Mnemiopsis leidyi and Its Implications for Cell Type Evolution

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dc.citation.firstpage1242592en_US
dc.citation.issueNumber6164en_US
dc.citation.journalTitleScienceen_US
dc.citation.volumeNumber342en_US
dc.contributor.authorRyan, Joseph F.en_US
dc.contributor.authorPang, Kevinen_US
dc.contributor.authorSchnitzler, Christine E.en_US
dc.contributor.authorNguyen, Anh-Daoen_US
dc.contributor.authorMoreland, R. Travisen_US
dc.contributor.authorSimmons, David K.en_US
dc.contributor.authorKoch, Bernard J.en_US
dc.contributor.authorFrancis, Warren R.en_US
dc.contributor.authorHavlak, Paulen_US
dc.contributor.authorNISC Comparative Sequencing Programen_US
dc.contributor.authorSmith, Stephen A.en_US
dc.contributor.authorPutnam, Nicholas H.en_US
dc.contributor.authorHaddock, Steven H.D.en_US
dc.contributor.authorDunn, Casey W.en_US
dc.contributor.authorWolfsberg, Tyra G.en_US
dc.contributor.authorMullikin, James C.en_US
dc.contributor.authorMartindale, Mark Q.en_US
dc.contributor.authorBaxevanis, Andreas D.en_US
dc.date.accessioned2015-07-10T15:47:01Z
dc.date.available2015-07-10T15:47:01Z
dc.date.issued2013en_US
dc.description.abstractAn understanding of ctenophore biology is critical for reconstructing events that occurred early in animal evolution. Toward this goal, we have sequenced, assembled, and annotated the genome of the ctenophore Mnemiopsis leidyi. Our phylogenomic analyses of both amino acid positions and gene content suggest that ctenophores rather than sponges are the sister lineage to all other animals. Mnemiopsis lacks many of the genes found in bilaterian mesodermal cell types, suggesting that these cell types evolved independently. The set of neural genes in Mnemiopsis is similar to that of sponges, indicating that sponges may have lost a nervous system. These results present a newly supported view of early animal evolution that accounts for major losses and/or gains of sophisticated cell types, including nerve and muscle cells.en_US
dc.identifier.citationRyan, Joseph F., Pang, Kevin, Schnitzler, Christine E., et al.. "The Genome of the Ctenophore Mnemiopsis leidyi and Its Implications for Cell Type Evolution." <i>Science,</i> 342, no. 6164 (2013) American Association for the Advancement of Science: 1242592. http://dx.doi.org/10.1126/science.1242592.
dc.identifier.doihttp://dx.doi.org/10.1126/science.1242592en_US
dc.identifier.urihttps://hdl.handle.net/1911/80884
dc.language.isoengen_US
dc.publisherAmerican Association for the Advancement of Science
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by AAAS.en_US
dc.titleThe Genome of the Ctenophore Mnemiopsis leidyi and Its Implications for Cell Type Evolutionen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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