Immunogenicity of Externally Activated Nanoparticles for Cancer Therapy

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dc.citation.articleNumber2559en_US
dc.citation.issueNumber12en_US
dc.citation.journalTitleCancersen_US
dc.citation.volumeNumber12en_US
dc.contributor.authorSahin, Onuren_US
dc.contributor.authorMeiyazhagan, Ashokkumaren_US
dc.contributor.authorAjayan, Pulickel M.en_US
dc.contributor.authorKrishnan, Sunilen_US
dc.contributor.orgMaterials Science and Nanoengineeringen_US
dc.date.accessioned2020-12-16T19:47:20Zen_US
dc.date.available2020-12-16T19:47:20Zen_US
dc.date.issued2020en_US
dc.description.abstractNanoparticles activated by external beams, such as ionizing radiation, laser light, or magnetic fields, have attracted significant research interest as a possible modality for treating solid tumors. From producing hyperthermic conditions to generating reactive oxygen species, a wide range of externally activated mechanisms have been explored for producing cytotoxicity within tumors with high spatiotemporal control. To further improve tumoricidal effects, recent trends in the literature have focused on stimulating the immune system through externally activated treatment strategies that result in immunogenic cell death. By releasing inflammatory compounds known to initiate an immune response, treatment methods can take advantage of immune system pathways for a durable and robust systemic anti-tumor response. In this review, we discuss recent advancements in radiosensitizing and hyperthermic nanoparticles that have been tuned for promoting immunogenic cell death. Our review covers both preclinical and clinical results, as well as an overview of possible future work.en_US
dc.identifier.citationSahin, Onur, Meiyazhagan, Ashokkumar, Ajayan, Pulickel M., et al.. "Immunogenicity of Externally Activated Nanoparticles for Cancer Therapy." <i>Cancers,</i> 12, no. 12 (2020) MDPI: https://doi.org/10.3390/cancers12123559.en_US
dc.identifier.digitalcancers-12-03559-v2en_US
dc.identifier.doihttps://doi.org/10.3390/cancers12123559en_US
dc.identifier.urihttps://hdl.handle.net/1911/109734en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subject.keywordradiosensitizing nanoparticlesen_US
dc.subject.keywordX-rayen_US
dc.subject.keywordrare-earth elementsen_US
dc.subject.keywordphotothermal therapyen_US
dc.subject.keywordphotodynamic therapyen_US
dc.subject.keywordmagnetic hyperthermiaen_US
dc.titleImmunogenicity of Externally Activated Nanoparticles for Cancer Therapyen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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